Systematic name M1618
Brief description Genes up-regulated in SW-13 cells (kidney cancer) by transient expression of SMARCA4 [GeneID=6597] at 24 h off a plasmid vector.
Full description or abstract The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF complex and the BAF-dependent activation of the promoter. Furthermore, the activation of the CSF1 promoter requires Z-DNA-forming sequences that are converted to Z-DNA structure upon activation by the BAF complex. The BAF complex facilitates Z-DNA formation in a nucleosomal template in vitro. We propose a model in which the BAF complex promotes Z-DNA formation which, in turn, stabilizes the open chromatin structure at the CSF1 promoter.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11509180   Authors: Liu R,Liu H,Chen X,Kirby M,Brown PO,Zhao K
Exact source Suppl. file BRG1resp.xls
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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Version history 3.1: First introduced

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