Human Gene Set: LU_EZH2_TARGETS_DN

Standard name LU_EZH2_TARGETS_DN
Systematic name M2140
Brief description Genes down-regulated in SKOV3ip1 cells (ovarian cancer) upon knockdown of EZH2 [GeneID=2146] by RNAi.
Full description or abstract Although VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homolog 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in endothelial EZH2 is a direct result of VEGF stimulation by a paracrine circuit that promotes angiogenesis by methylating and silencing vasohibin1 (vash1). Ezh2 silencing in the tumor-associated endothelial cells inhibited angiogenesis mediated by reactivation of VASH1, and reduced ovarian cancer growth, which is further enhanced in combination with ezh2 silencing in tumor cells. Collectively, these data support the potential for targeting ezh2 as an important therapeutic approach.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20708159   Authors: Lu C,Han HD,Mangala LS,Ali-Fehmi R,Newton CS,Ozbun L,Armaiz-Pena GN,Hu W,Stone RL,Munkarah A,Ravoori MK,Shahzad MM,Lee JW,Mora E,Langley RR,Carroll AR,Matsuo K,Spannuth WA,Schmandt R,Jennings NB,Goodman BW,Jaffe RB,Nick AM,Kim HS,Guven EO,Chen YH,Li LY,Hsu MC,Coleman RL,Calin GA,Denkbas EB,Lim JY,Lee JS,Kundra V,Birrer MJ,Hung MC,Lopez-Berestein G,Sood AK
Exact source Fig 5SJ: personal communication
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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Version history 3.1: First introduced

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