Standard name |
MARTINELLI_IMMATURE_NEUTROPHIL_UP |
Systematic name |
M14418 |
Brief description |
Neutrophil-specific genes up-regulated in comparison of immature with mature neutrophils. |
Full description or abstract |
Interferons (IFNs) are cytokines that possess potent anti-viral and immunoregulatory activities. In contrast, their potential role(s) in anti-bacterial defense and neutrophil activation mechanisms is less well explored. By comparing gene expression patterns between immature and mature human neutrophils, we obtained evidence that intracellular proteases and other anti-bacterial proteins are produced at earlier stages of maturation, whereas the genes for receptors and signaling molecules required for the release of these effector molecules are preferentially induced during terminal differentiation. For instance, mature neutrophils strongly expressed genes that increase their responses to type I and type II IFNs. Interestingly, granulocyte/macrophage colony-stimulating factor was identified as a repressor of IFN signaling components and consequently of IFN-responsive genes. Both IFN-alpha and IFN-gamma induced strong tyrosine phosphorylation of STAT1 in mature but not in immature neutrophils. Functional in vitro studies suggested that IFNs act as priming factors on mature neutrophils, allowing the formation of extracellular traps upon subsequent stimulation with complement factor 5a (C5a). In contrast, both IFN-alpha and IFN-gamma had only little capacity to prime immature cells in this system. Moreover, both IFNs did not have significant anti-proliferative effects on immature neutrophils. These data contribute to our understanding regarding changes of gene expression during neutrophil differentiation and IFN-mediated anti-bacterial defense mechanisms. |
Collection |
C2: Curated CGP: Chemical and Genetic Perturbations |
Source publication |
Pubmed 15302890 Authors: Martinelli S,Urosevic M,Daryadel A,Oberholzer PA,Baumann C,Fey MF,Dummer R,Simon HU,Yousefi S |
Exact source |
Table 4: Immature neutrophils |
Related gene sets |
(show 1 additional gene sets from the source publication)
(show 11 gene sets from the same authors)
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External links |
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Source species |
Homo sapiens |
Contributed by |
Arthur Liberzon (MSigDB Team) |
Source platform or identifier namespace |
HUMAN_SEQ_ACCESSION |
Dataset references |
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Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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(show 12 source identifiers mapped to 11 genes)
Source Id |
NCBI (Entrez) Gene Id |
Gene Symbol |
Gene Description |
AI250799 |
1669 |
DEFA4 |
defensin alpha 4 [Source:HGNC Symbol;Acc:HGNC... |
AI762213 |
3934 |
LCN2 |
lipocalin 2 [Source:HGNC Symbol;Acc:HGNC:6526] |
AL036554 |
1667 |
DEFA1 |
defensin alpha 1 [Source:HGNC Symbol;Acc:HGNC... |
J04739 |
671 |
BPI |
bactericidal permeability increasing protein ... |
J04990 |
1511 |
CTSG |
cathepsin G [Source:HGNC Symbol;Acc:HGNC:2532] |
J05556 |
4317 |
MMP8 |
matrix metallopeptidase 8 [Source:HGNC Symbol... |
M16117 |
1511 |
CTSG |
cathepsin G [Source:HGNC Symbol;Acc:HGNC:2532] |
M19507 |
4353 |
MPO |
myeloperoxidase [Source:HGNC Symbol;Acc:HGNC:... |
M34379 |
1991 |
ELANE |
elastase, neutrophil expressed [Source:HGNC S... |
M96326 |
566 |
AZU1 |
azurocidin 1 [Source:HGNC Symbol;Acc:HGNC:913] |
X04011 |
1536 |
CYBB |
cytochrome b-245 beta chain [Source:HGNC Symb... |
Z38026 |
820 |
CAMP |
cathelicidin antimicrobial peptide [Source:HG... |
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