Gene Set: MCCLUNG_CREB1_TARGETS_UP

Standard name MCCLUNG_CREB1_TARGETS_UP
Systematic name M6920
Brief description Genes up-regulated in the nucleus accumbens (a major reward center in the brain) 8 weeks after induction of CREB1 [GeneID=1385] expression in a transgenic Tet-Off system.
Full description or abstract DeltaFosB (a truncated form of FosB) and CREB (cAMP response element binding protein) are transcription factors induced in the brain's reward pathways after chronic exposure to drugs of abuse. However, their mechanisms of action and the genes they regulate remain unclear. Using microarray analysis in the nucleus accumbens of inducible transgenic mice, we found that CREB and a dominant-negative CREB have opposite effects on gene expression, as do prolonged expression of DeltaFosB and the activator protein-1 (AP-1) antagonist DeltacJun. However, unlike CREB, short-term and prolonged DeltaFosB induction had opposing effects on gene expression. Gene expression induced by short-term DeltaFosB and by CREB was strikingly similar, and both reduced the rewarding effects of cocaine, whereas prolonged DeltaFosB expression increased drug reward. Gene expression after a short cocaine treatment was more dependent on CREB, whereas gene expression after a longer cocaine treatment became increasingly DeltaFosB dependent. These findings help define the molecular functions of CREB and DeltaFosB and identify clusters of genes that contribute to cocaine addiction.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 14566342   Authors: McClung CA,Nestler EJ
Exact source Table 1S
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform AFFY_MG_U74
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Version history 3.0: Renamed from CREB_BRAIN_8WKS_UP

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