Gene Set: MODY_HIPPOCAMPUS_NEONATAL

Standard name MODY_HIPPOCAMPUS_NEONATAL
Systematic name M7409
Brief description Genes highly expressed in the neonatal hippocampus (clusters 4 and 8).
Full description or abstract We have analyzed the developmental molecular programs of the mouse hippocampus, a cortical structure critical for learning and memory, by means of large-scale DNA microarray techniques. Of 11,000 genes and expressed sequence tags examined, 1,926 showed dynamic changes during hippocampal development from embryonic day 16 to postnatal day 30. Gene-cluster analysis was used to group these genes into 16 distinct clusters with striking patterns that appear to correlate with major developmental hallmarks and cellular events. These include genes involved in neuronal proliferation, differentiation, and synapse formation. A complete list of the transcriptional changes has been compiled into a comprehensive gene profile database (http://BrainGenomics.Princeton.edu), which should prove valuable in advancing our understanding of the molecular and genetic programs underlying both the development and the functions of the mammalian brain.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11438693   Authors: Mody M,Cao Y,Cui Z,Tay KY,Shyong A,Shimizu E,Pham K,Schultz P,Welsh D,Tsien JZ
Exact source Table 2S
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(show 9 gene sets from the same authors)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform AFFY_Mu11K
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Version history 3.0: Renamed from HIPPOCAMPUS_DEVELOPMENT_NEONATAL

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