Systematic name M389
Brief description Top 50 most-increased mast cell specific genes.
Full description or abstract Mast cells (MCs) and eosinophils are thought to play important roles in evoking allergic inflammation. Cell-type--specific gene expression was screened among 12,000 genes in human MCs and eosinophils with the use of high-density oligonucleotide probe arrays. In comparison with other leukocytes, MCs expressed 140 cell-type--specific transcripts, whereas eosinophils expressed only 34. Among the transcripts for expected MC-specific proteins such as tryptase, major basic protein (MBP), which had been thought to be eosinophil specific, was ranked fourth in terms of amounts of increased MC-specific messenger RNA. Mature eosinophils were almost lacking this transcript. MCs obtained from 4 different sources (ie, lung, skin, adult peripheral blood progenitor--derived and cord blood progenitor--derived MCs, and eosinophils) were found to have high protein levels of MBP in their granules with the use of flow cytometric and confocal laser scanning microscopic analyses. The present finding that MCs can produce abundant MBP is crucial because many reports regarding allergic pathogenesis have been based on earlier findings that MBP was almost unique to eosinophils and not produced by MCs. (Blood. 2001;98:1127-1134)
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11493461   Authors: Nakajima T,Matsumoto K,Suto H,Tanaka K,Ebisawa M,Tomita H,Yuki K,Katsunuma T,Akasawa A,Hashida R,Sugita Y,Ogawa H,Ra C,Saito H
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Source species Homo sapiens
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Version history 3.0: Renamed from NAKAJIMA_MCSMBP_MAST

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