Gene Set: OKUMURA_INFLAMMATORY_RESPONSE_LPS

Standard name OKUMURA_INFLAMMATORY_RESPONSE_LPS
Systematic name M1911
Brief description Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS).
Full description or abstract Rodent mast cells (MCs) are reported to play a pivotal role in both innate and adaptive immunity. However, there is so far no evidence that human MCs are involved in innate immunity. We found that a functional Toll-like receptor 4 (TLR4) was expressed on human MCs when it was up-regulated by interferon gamma (IFN-gamma). To systematically explore how human MCs modulate the immune system following TLR4-mediated activation and FcepsilonRI aggregation, we used high-density oligonucleotide probe arrays (GeneChip) to compare the lipopolysaccharide (LPS)-induced gene expression profile with the IgE/anti-IgE-mediated profile in MCs. Both a shared core response, and LPS- or anti-IgE-specific programs of gene expression were observed in MCs. Furthermore, MCs exhibited an antiviral response gene program in response to IFN-gamma, and LPS sustained that expression. Compared with the LPS-stimulated gene expression profile of human peripheral blood mononuclear cells, LPS-stimulated MCs specifically induced a subset of genes that included a Th2 cytokine and chemokines that recruit Th2 cells and eosinophils. These results reveal that human MCs express tailored pathogen- and antigen-specific immune responses and that human MCs may play important roles in innate and adaptive immunity.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12855579   Authors: Okumura S,Kashiwakura J,Tomita H,Matsumoto K,Nakajima T,Saito H,Okayama Y
Exact source Table 3-IS
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Organism Homo sapiens
Contributed by Kate Stafford (MSigDB Team)
Source platform AFFY_HG_U133
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Version history 3.0: Renamed from OKUMURA_MC_LPS

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