Human Gene Set: PDGF_ERK_DN.V1_UP

Standard name PDGF_ERK_DN.V1_UP
Systematic name M2830
Brief description Genes up-regulated in SH-SY5Y cells (neuroblastoma) in response to PDGF [Gene ID=] stimulation after pre-treatment with the ERK inhibitors U0126 and PD98059 [PubChem=3006531] [PubChem=4713].
Full description or abstract To define ERK/PDGFR activation signature, SH-SY5Y cells were grown to confluence and starved overnight in serum-free medium in order to silence any sustained effects from growth factor signaling. Prior to induction with 50ng/ml PDGF, cells were treated with pathway inhibitors 74 mM Apigenin or 50 mM U0126, or with DMSO (carrier) for 60 minutes. Total RNA was isolated 30 minutes after PDGF addition. Experiments were performed in duplicate. The RNA was processed and hybridized with Affymetrix U133A GeneChips.
Collection C6: Oncogenic Signature
Source publication Pubmed 18312689   Authors: Antipova AA,Stockwell BR,Golub TR
Exact source PDGF stimulation after ERL inhibition vs Controls; top 300 genes (diff. of means)
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Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
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