Human Gene Set: QUINTENS_EMBRYONIC_BRAIN_RESPONSE_TO_IR

For the Mouse gene set with the same name, see QUINTENS_EMBRYONIC_BRAIN_RESPONSE_TO_IR

Standard name QUINTENS_EMBRYONIC_BRAIN_RESPONSE_TO_IR
Systematic name M39
Brief description Genes up-regulated in the mouse embryonic brain or immature neurons at 2 h or 6 h, respectively after exposure to 1 Gy dose of ionizing radiation.
Full description or abstract The mammalian brain is especially sensitive to ionizing radiation during development, as shown by the increased occurrence of mental retardation and small head size in children who were in utero exposed to ionizing radiation after the atomic bombings of Hiroshima and Nagasaki. These effects of prenatal irradiation can be mimicked by irradiation of mouse embryos during the organogenesis period. In order to better understand the early effects of ionizing radiation on the embryonic brain and immature neurons, we performed a microarray analysis on brains from mice irradiated with different doses at E11 and E14, as well as primary cortical neuron cultures at 14 h in vitro. RNA was extracted at either 2 h (brains) or 6 h (neurons) post-irradiation. This gene set includes genes that were differentially expressed in at least two different conditions, to generate a bona fide list of early radiation-responsive genes in the embryonic mouse brain.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 25681390   Authors: Quintens R,Verreet T,Janssen A,Neefs M,Leysen L,Michaux A,Verslegers M,Samari N,Pani G,Verheyde J,Baatout S,Benotmane MA
Exact source Table S3.
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Source species Mus musculus
Contributed by Roel Quintens (Belgian Nuclear Research Centre)
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identifier namespace		 AFFY_MoGene
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Version history 6.2: changed members

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