Systematic name M7815
Brief description The 'Bullinger validation signature' [PMID=15084693] used to validate prediction of prognostic outcome of acute myeloid leukemia (AML) patients with a normal karyotype.
Full description or abstract Patients with acute myeloid leukemia (AML) and normal karyotype are classified in an intermediate-risk group, albeit this subset is heterogeneous for clinical outcome. A recent complementary DNA microarray study identified a gene-expression signature that--when used to cluster normal karyotype patients--separated them into 2 prognostically relevant subgroups. We sought the first independent validation of the prognostic value of this signature. Using oligonucleotide microarrays to measure gene expression in samples from uniformly treated adults with karyotypically normal AML, we performed cluster analysis based on the previously identified signature. We also developed a well-defined classification rule using the signature to predict outcome for individual patients. Cluster analysis confirmed the prognostic utility of the signature: patient clusters differed in overall (P = .001) and disease-free (P = .001) survival. The signature-based classifier identified groups with differences in overall (P = .02) and disease-free (P = .05) survival. A strong association of the outcome classifier with the prognostically adverse FLT3 internal tandem duplication (FLT3 ITD) potentially explained the prognostic significance of the signature. However, in the subgroup of patients without FLT3 ITD there was a moderate difference in survival for the classifier-derived groups. Our analysis confirms the applicability of the gene-expression profiling strategy for outcome prediction in cytogenetically normal AML.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16670265   Authors: Radmacher MD,Marcucci G,Ruppert AS,Mrůzek K,Whitman SP,Vardiman JW,Paschka P,Vukosavljevic T,Baldus CD,Kolitz JE,Caligiuri MA,Larson RA,Bloomfield CD,Cancer and Leukemia Group B
Exact source Table 1S
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Source species Homo sapiens
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Version history 3.0: Renamed from RADMACHER_AMLNORMALKARYTYPE_SIG

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