Systematic name M11893
Brief description A biomarker of plasma signaling proteins that predicts clinical Alzheimer's diagnosis.
Full description or abstract A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17934472   Authors: Ray S,Britschgi M,Herbert C,Takeda-Uchimura Y,Boxer A,Blennow K,Friedman LF,Galasko DR,Jutel M,Karydas A,Kaye JA,Leszek J,Miller BL,Minthon L,Quinn JF,Rabinovici GD,Robinson WH,Sabbagh MN,So YT,Sparks DL,Tabaton M,Tinklenberg J,Yesavage JA,Tibshirani R,Wyss-Coray T
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