Gene Set: REICHERT_MITOSIS_LIN9_TARGETS

Standard name REICHERT_MITOSIS_LIN9_TARGETS
Systematic name M2483
Brief description Genes with known mitosis function that were down-regulated in MEF cells (embryonic fibroblast) upon knockout of LIN9 [GeneID=286826].
Full description or abstract The retinoblastoma tumor suppressor protein (pRB) and related p107 and p130 pocket proteins function together with the E2F transcription factors to repress gene expression during the cell cycle and development. Recent biochemical studies have identified the multisubunit DREAM pocket protein complexes in Drosophila melanogaster and Caenorhabditis elegans in regulating developmental gene repression. Although a conserved DREAM complex has also been identified in mammalian cells, its physiological function in vivo has not been determined. Here we addressed this question by targeting Lin9, a conserved core subunit of DREAM. We found that LIN9 is essential for early embryonic development and for viability of adult mice. Loss of Lin9 abolishes proliferation and leads to multiple defects in mitosis and cytokinesis because of its requirement for the expression of a large set of mitotic genes, such as Plk1, Aurora A, and Kif20a. While Lin9 heterozygous mice are healthy and normal, they are more susceptible to lung tumorigenesis induced by oncogenic c-Raf than wild-type mice. Together these experiments provide the first direct genetic evidence for the role of LIN9 in development and mitotic gene regulation and they suggest that it may function as a haploinsufficient tumor suppressor.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 20404087   Authors: Reichert N,Wurster S,Ulrich T,Schmitt K,Hauser S,Probst L,Götz R,Ceteci F,Moll R,Rapp U,Gaubatz S
Exact source Fig. 6C
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform MOUSE_GENE_SYMBOL
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Version history 3.1: First introduced

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