Systematic name M15009
Brief description Genes down-regulated in Kelly cells (neuroblastoma) by overexpressing INHBA [GeneID=3624] off a plasmid vector.
Full description or abstract Amplification of the MYCN oncogene contributes to the malignant progression of human neuroblastomas, but the mechanisms have remained unclear. We have previously demonstrated that N-Myc facilitates angiogenesis by downregulating an angiogenesis inhibitor identified as the inhibin betaA homodimer activin A. Here, we have sought to define the molecular, biological and clinical consequences of activin A expression in human neuroblastoma. We report that enhanced activin A expression suppresses proliferation and colony formation of human neuroblastoma cells with amplified MYCN in vitro; that it inhibits neuroblastoma growth and angiogenesis in vivo; that it is highly expressed in differentiated, but not undifferentiated human neuroblastomas; and that it correlates with favourable outcome of neuroblastoma patients. Our results indicate that high activin A expression plays an important beneficial role in human neuroblastoma.
Collection ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
      C2_CGP: Archived chemical and genetic perturbations
Source publication Pubmed 15580313   Authors: Schramm A,von Schuetz V,Christiansen H,Havers W,Papoutsi M,Wilting J,Schweigerer L
Exact source Table 1: Down in KT3
Related gene sets (show 1 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform UniGene_ID
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps
Compendia expression profiles
Advanced query
Gene families
Show members (show 24 members mapped to 0 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.