Systematic name M12299
Brief description Genes that are transcriptionally regulated by HIF1A [GeneID=3091].
Full description or abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1beta subunit is constitutively expressed, whereas the HIF-1alpha subunit is subject to ubiquitination and proteasomal degradation, a process that is inhibited under hypoxic conditions. Recent data indicate that HIF-1 plays major roles in the prevention of myocardial and cerebral ischemia and in the pathogenesis of pulmonary hypertension and cancer. Modulation of HIF-1 activity by genetic or pharmacological means could provide a novel therapeutic approach to these common causes of mortality.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 11516994   Authors: Semenza GL
Exact source Table 1
Related gene sets (show 2 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by John Newman (University of Washington)
Source platform or
identifier namespace
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 36 genes
Gene families ? Categorize these 36 genes by gene family
Show members (show 36 source identifiers mapped to 36 genes)
Version history 3.0: Renamed from HIF1_TARGETS

See MSigDB license terms here. Please note that certain gene sets have special access terms.