Gene Set: SEMENZA_HIF1_TARGETS

Standard name SEMENZA_HIF1_TARGETS
Systematic name M12299
Brief description Genes that are transcriptionally regulated by HIF1A [GeneID=3091].
Full description or abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to reduced oxygen availability. The HIF-1beta subunit is constitutively expressed, whereas the HIF-1alpha subunit is subject to ubiquitination and proteasomal degradation, a process that is inhibited under hypoxic conditions. Recent data indicate that HIF-1 plays major roles in the prevention of myocardial and cerebral ischemia and in the pathogenesis of pulmonary hypertension and cancer. Modulation of HIF-1 activity by genetic or pharmacological means could provide a novel therapeutic approach to these common causes of mortality.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11516994   Authors: Semenza GL
Exact source Table 1
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform HUMAN_GENE_SYMBOL
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Version history 3.0: Renamed from HIF1_TARGETS

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