Human Gene Set: SERVITJA_ISLET_HNF1A_TARGETS_UP

For the Mouse gene set with the same name, see SERVITJA_ISLET_HNF1A_TARGETS_UP

Standard name SERVITJA_ISLET_HNF1A_TARGETS_UP
Systematic name M2395
Brief description Genes up-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927].
Full description or abstract Heterozygous HNF1A mutations cause pancreatic-islet beta-cell dysfunction and monogenic diabetes (MODY3). Hnf1alpha is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more limited. We now show that Hnf1a deficiency in mice leads to highly tissue-specific changes in the expression of genes involved in key functions of both islets and liver. To gain insights into the mechanisms of tissue-specific Hnf1alpha regulation, we integrated expression studies of Hnf1a-deficient mice with identification of direct Hnf1alpha targets. We demonstrate that Hnf1alpha can bind in a tissue-selective manner to genes that are expressed only in liver or islets. We also show that Hnf1alpha is essential only for the transcription of a minor fraction of its direct-target genes. Even among genes that were expressed in both liver and islets, the subset of targets showing functional dependence on Hnf1alpha was highly tissue specific. This was partly explained by the compensatory occupancy by the paralog Hnf1beta at selected genes in Hnf1a-deficient liver. In keeping with these findings, the biological consequences of Hnf1a deficiency were markedly different in islets and liver. Notably, Hnf1a deficiency led to impaired large-T-antigen-induced growth and oncogenesis in beta cells yet enhanced proliferation in hepatocytes. Collectively, these findings show that Hnf1alpha governs broad, highly tissue-specific genetic programs in pancreatic islets and liver and reveal key consequences of Hnf1a deficiency relevant to the pathophysiology of monogenic diabetes.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 19289501   Authors: Servitja JM,Pignatelli M,Maestro MA,Cardalda C,Boj SF,Lozano J,Blanco E,Lafuente A,McCarthy MI,Sumoy L,Guigó R,Ferrer J
Exact source Table 2S
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Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
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Version history 3.1: First introduced

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