Human Gene Set: SHEPARD_BMYB_MORPHOLINO_UP


Standard name SHEPARD_BMYB_MORPHOLINO_UP
Systematic name M10209
Brief description Human orthologs of genes up-regulated in zebra fish after knockdown of BMYB [GeneID=4605] by morpholino.
Full description or abstract A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale genetic screens in uncovering human disease genes, makes zebrafish an ideal system in which to find such new genes. Here, we show that a zebrafish forward genetic screen uncovered multiple cell proliferation mutants including one mutant, crash&burn (crb), that represents a loss-of-function mutation in bmyb, a transcriptional regulator and member of a putative proto-oncogene family. crb mutant embryos have defects in mitotic progression and spindle formation, and exhibit genome instability. Regulation of cyclin B levels by bmyb appears to be the mechanism of mitotic accumulation in crb. Carcinogenesis studies reveal increased cancer susceptibility in adult crb heterozygotes. Gene-expression signatures associated with loss of bmyb in zebrafish are also correlated with conserved signatures in human tumor samples, and down-regulation of the B-myb signature genes is associated with retention of p53 function. Our findings show that zebrafish screens can uncover cancer pathways, and demonstrate that loss of function of bmyb is associated with cancer.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16150706   Authors: Shepard JL,Amatruda JF,Stern HM,Subramanian A,Finkelstein D,Ziai J,Finley KR,Pfaff KL,Hersey C,Zhou Y,Barut B,Freedman M,Lee C,Spitsbergen J,Neuberg D,Weber G,Golub TR,Glickman JN,Kutok JL,Aster JC,Zon LI
Exact source Table 1S
Related gene sets (show 4 additional gene sets from the source publication)

(show 305 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Danio rerio
Contributed by Jennifer Shepard (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 212 genes
Gene families ? Categorize these 212 genes by gene family
Show members (show 216 source identifiers mapped to 212 genes)
Version history 3.0: Renamed from SHEPARD_BMYB_MORPHOLINO_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.