Human Gene Set: SIRNA_EIF4GI_DN

Standard name SIRNA_EIF4GI_DN
Systematic name M2846
Brief description Genes down-regulated in MCF10A cells vs knockdown of EIF4G1 [GeneID=1981] gene by RNAi.
Full description or abstract eIF4GI Links Nutrient Sensing by mTOR to Cell Proliferation and Inhibition of Autophagy. Two sets of experiments are presented. First, overall transcriptome changes were determined for control or eIF4GI silenced cells. Next, mRNAs associated with polysomes were compared between control and eIF4GI silenced cells.
Collection C6: Oncogenic Signature
Source publication Pubmed 18426977   Authors: Ramírez-Valle F,Braunstein S,Zavadil J,Formenti SC,Schneider RJ
Exact source control vs RNAi KD eIFGI; bottom 100 genes (diff. of means)
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Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
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