Systematic name M12802
Brief description Genes from the recurrent amplicons in 89 samples of oral squamous cell carcinoma (SCC).
Full description or abstract Genomes of solid tumors are characterized by gains and losses of regions, which may contribute to tumorigenesis by altering gene expression. Often the aberrations are extensive, encompassing whole chromosome arms, which makes identification of candidate genes in these regions difficult. Here, we focused on narrow regions of gene amplification to facilitate identification of genetic pathways important in oral squamous cell carcinoma (SCC) development. We used array comparative genomic hybridization (array CGH) to define minimum common amplified regions and then used expression analysis to identify candidate driver genes in amplicons that spanned <3 Mb. We found genes involved in integrin signaling (TLN1), survival (YAP1, BIRC2), and adhesion and migration (TLN1, LAMA3, MMP7), as well as members of the hedgehog (GLI2) and notch (JAG1, RBPSUH, FJX1) pathways to be amplified and overexpressed. Deregulation of these and other members of the hedgehog and notch pathways (HHIP, SMO, DLL1, NOTCH4) implicates deregulation of developmental and differentiation pathways, cell fate misspecification, in oral SCC development.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15824737   Authors: Snijders AM,Schmidt BL,Fridlyand J,Dekker N,Pinkel D,Jordan RC,Albertson DG
Exact source Table 2
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Source species Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
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Version history 3.0: First introduced

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