Human Gene Set: SUNG_METASTASIS_STROMA_DN


Standard name SUNG_METASTASIS_STROMA_DN
Systematic name M2904
Brief description Genes down-regulated in metastatic vs non-metastatic stromal cells originated from either bone or prostate tissues.
Full description or abstract Human bone stromal cells, after three-dimensional coculture with human prostate cancer (PCa) cells in vitro, underwent permanent cytogenetic and gene expression changes with reactive oxygen species serving as mediators. The evolved stromal cells are highly inductive of human PCa growth in mice, and expressed increased levels of extracellular matrix (versican and tenascin) and chemokine (BDFN, CCL5, CXCL5, and CXCL16) genes. These genes were validated in clinical tissue and/or serum specimens and could be the predictors for invasive and bone metastatic PCa. These results, combined with our previous observations, support the concept of permanent genetic and behavioral changes of PCa epithelial cells after being either cocultured with prostate or bone stromal cells as three-dimensional prostate organoids or grown as tumor xenografts in mice. These observations collectively suggest coevolution of cancer and stromal cells occurred under three-dimensional growth condition, which ultimately accelerates cancer growth and metastasis.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 19047182   Authors: Sung SY,Hsieh CL,Law A,Zhau HE,Pathak S,Multani AS,Lim S,Coleman IM,Wu LC,Figg WD,Dahut WL,Nelson P,Lee JK,Amin MB,Lyles R,Johnstone PA,Marshall FF,Chung LW
Exact source Table 2S
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Source species Homo sapiens
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 Human_NCBI_Gene_ID
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Version history 3.0: First introduced

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