Human Gene Set: SWEET_LUNG_CANCER_KRAS_DN

For the Mouse gene set with the same name, see SWEET_LUNG_CANCER_KRAS_DN

Standard name SWEET_LUNG_CANCER_KRAS_DN
Systematic name M7396
Brief description Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845].
Full description or abstract Using advanced gene targeting methods, generating mouse models of cancer that accurately reproduce the genetic alterations present in human tumors is now relatively straightforward. The challenge is to determine to what extent such models faithfully mimic human disease with respect to the underlying molecular mechanisms that accompany tumor progression. Here we describe a method for comparing mouse models of cancer with human tumors using gene-expression profiling. We applied this method to the analysis of a model of Kras2-mediated lung cancer and found a good relationship to human lung adenocarcinoma, thereby validating the model. Furthermore, we found that whereas a gene-expression signature of KRAS2 activation was not identifiable when analyzing human tumors with known KRAS2 mutation status alone, integrating mouse and human data uncovered a gene-expression signature of KRAS2 mutation in human lung cancer. We confirmed the importance of this signature by gene-expression analysis of short hairpin RNA-mediated inhibition of oncogenic Kras2. These experiments identified both a pattern of gene expression indicative of KRAS2 mutation and potential effectors of oncogenic KRAS2 activity in human cancer. This approach provides a strategy for using genomic analysis of animal models to probe human disease.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15608639   Authors: Sweet-Cordero A,Mukherjee S,Subramanian A,You H,Roix JJ,Ladd-Acosta C,Mesirov J,Golub TR,Jacks T
Exact source Table 2S
Related gene sets (show 4 additional gene sets from the source publication)

(show 285 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace
AFFY_MG_U74
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 422 genes
Gene families ? Categorize these 422 genes by gene family
Show members (show 510 source identifiers mapped to 422 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.