Human Gene Set: TGFB_UP.V1_DN

Standard name TGFB_UP.V1_DN
Systematic name M2838
Brief description Genes down-regulated in a panel of epithelial cell lines by TGFB1 [GeneID=7040].
Full description or abstract A gene expression signature typifying the TGFbeta response in human epithelial cells was obtained from transcriptomic analysis of four human cell lines (Figure 1A, Supplementary Figure 1). These cell lines include HaCaT keratinocytes, HPL1 immortalized lung epithelial cells, MCF10A breast epithelial cells, and MDA-MB-231 breast carcinoma cells. The cells were treated with TGFB1 for 3 h in order to capture direct TGFbeta gene responses .
Collection C6: Oncogenic Signature
Source publication Pubmed 18394990   Authors: Padua D,Zhang XH,Wang Q,Nadal C,Gerald WL,Gomis RR,Massagué J
Exact source stimulation with TGFB vs control; bottom 200 genes
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Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
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