Human Gene Set: TGFB_UP.V1_DN


Standard name TGFB_UP.V1_DN
Systematic name M2838
Brief description Genes down-regulated in a panel of epithelial cell lines by TGFB1 [GeneID=7040].
Full description or abstract A gene expression signature typifying the TGFbeta response in human epithelial cells was obtained from transcriptomic analysis of four human cell lines (Figure 1A, Supplementary Figure 1). These cell lines include HaCaT keratinocytes, HPL1 immortalized lung epithelial cells, MCF10A breast epithelial cells, and MDA-MB-231 breast carcinoma cells. The cells were treated with TGFB1 for 3 h in order to capture direct TGFbeta gene responses .
Collection C6: Oncogenic Signature
Source publication Pubmed 18394990   Authors: Padua D,Zhang XH,Wang Q,Nadal C,Gerald WL,Gomis RR,Massagué J
Exact source stimulation with TGFB vs control; bottom 200 genes
Related gene sets (show 1 additional gene sets from the source publication)

(show 30 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 191 genes
Gene families ? Categorize these 191 genes by gene family
Show members (show 200 source identifiers mapped to 191 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.