Systematic name M1667
Brief description Genes down-regulated after heat shock in peripheral lympocytes from old donors, compared to those from the young ones.
Full description or abstract Ageing results in a progressive, intrinsic and generalised imbalance of the control of regulatory systems. A key manifestation of this complex biological process includes the attenuation of the universal stress response. Here we provide the first global assessment of the ageing process as it affects the heat shock response, utilising human peripheral lymphocytes and cDNA microarray analysis. The genomic approach employed in our preliminary study was supplemented with a proteomic approach. In addition, the current study correlates the in vivo total antioxidant status with the age-related differential gene expression as well as the translational kinetics of heat shock proteins (hsps). Most of the genes encoding stress response proteins on the 4224 element microarray used in this study were significantly elevated after heat shock treatment of lymphocytes obtained from both young and old individuals albeit to a greater extent in the young. Cell signaling and signal transduction genes as well as some oxidoreductases showed varied response. Results from translational kinetics of induction of major hsps, from 0 to 24 h recovery period were broadly consistent with the differential expression of HSC 70 and HSP 40 genes. Total antioxidant levels in plasma from old individuals were found to be significantly lower by comparison with young, in agreement with the widely acknowledged role of oxidant homeostasis in the ageing process.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12618007   Authors: Visala Rao D,Boyle GM,Parsons PG,Watson K,Jones GL
Exact source Table 1: increase in young
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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