Gene Set: WANG_LSD1_TARGETS_DN

Standard name WANG_LSD1_TARGETS_DN
Systematic name M1760
Brief description Genes down-regulated after Cre-lox knockout of LSD1 [GeneID=23028] in pituitary.
Full description or abstract Precise control of transcriptional programmes underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies. One thing that remains unclear is how specific members of histone modification enzyme families, such as histone methyltransferases and demethylases, are used in vivo to simultaneously orchestrate distinct developmental gene activation and repression programmes. Here, we report that the histone lysine demethylase, LSD1--a component of the CoREST-CtBP co-repressor complex--is required for late cell-lineage determination and differentiation during pituitary organogenesis. LSD1 seems to act primarily on target gene activation programmes, as well as in gene repression programmes, on the basis of recruitment of distinct LSD1-containing co-activator or co-repressor complexes. LSD1-dependent gene repression programmes can be extended late in development with the induced expression of ZEB1, a Krüppel-like repressor that can act as a molecular beacon for recruitment of the LSD1-containing CoREST-CtBP co-repressor complex, causing repression of an additional cohort of genes, such as Gh, which previously required LSD1 for activation. These findings suggest that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17392792   Authors: Wang J,Scully K,Zhu X,Cai L,Zhang J,Prefontaine GG,Krones A,Ohgi KA,Zhu P,Garcia-Bassets I,Liu F,Taylor H,Lozach J,Jayes FL,Korach KS,Glass CK,Fu XD,Rosenfeld MG
Exact source Fig 4AS
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Organism Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
Source platform MOUSE_GENE_SYMBOL
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Version history 3.1: First introduced

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