Systematic name M1542
Brief description Genes up-regulated in embryonic stem cells from TCEB3 [GeneID=6924] knockout mice.
Full description or abstract Elongin A is a transcription elongation factor that increases the overall rate of mRNA chain elongation by RNA polymerase II. To investigate the function of Elongin A in vivo, the two alleles of the Elongin A gene have been disrupted by homologous recombination in murine embryonic stem (ES) cells. The Elongin A-deficient ES cells are viable, but show a slow growth phenotype because they undergo a delayed mitosis. The cDNA microarray and RNase protection assay using the wild-type and Elongin A-deficient ES cells indicate that the expression of only a small subset of genes is affected in the mutant cells. Taken together, our results suggest that Elongin A regulates transcription of a subset but not all of genes and reveal a linkage between Elongin A function and cell cycle progression.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12604609   Authors: Yamazaki K,Aso T,Ohnishi Y,Ohno M,Tamura K,Shuin T,Kitajima S,Nakabeppu Y
Exact source Table 2S
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Organism Mus musculus
Contributed by John Newman (University of Washington)
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Version history 3.1: First introduced

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