Human Gene Set: YUAN_ZNF143_PARTNERS

Standard name YUAN_ZNF143_PARTNERS
Systematic name M2355
Brief description Proteins associated with ZNF143 [GeneID=7702] in HeLa cells, based on MudPIT analysis.
Full description or abstract Chromatin remodeling and histone modification are essential for eukaryotic transcription regulation, but little is known about chromatin-modifying activities acting on RNA polymerase III (Pol III)-transcribed genes. The human U6 small nuclear RNA promoter, located 5' of the transcription start site, consists of a core region directing basal transcription and an activating region that recruits the transcription factors Oct-1 and Staf (ZNF143). Oct-1 activates transcription in part by helping recruit core binding factors, but nothing is known about the mechanisms of transcription activation by Staf. We show that Staf activates U6 transcription from a preassembled chromatin template in vitro and associates with several proteins linked to chromatin modification, among them chromodomain-helicase-DNA binding protein 8 (CHD8). CHD8 binds to histone H3 di- and trimethylated on lysine 4. It resides on the human U6 promoter as well as the mRNA IRF3 promoter in vivo and contributes to efficient transcription from both these promoters. Thus, Pol III transcription from type 3 promoters uses some of the same factors used for chromatin remodeling at Pol II promoters.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17938208   Authors: Yuan CC,Zhao X,Florens L,Swanson SK,Washburn MP,Hernandez N
Exact source Fig. 2B
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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Version history 3.1: First introduced

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