Gene Set: ZHANG_PROLIFERATING_VS_QUIESCENT

Standard name ZHANG_PROLIFERATING_VS_QUIESCENT
Systematic name M16992
Brief description Genes up-regulated in HDMEC cells (microvascular endothelium): proliferating vs quiescent cells.
Full description or abstract Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothelial cells in the proliferative and quiescent state. Cells were stimulated by a combination of known growth factors for these cells including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and 'endothelial cell growth supplement (ECGS)' either alone or in combination. Analysis showed the expression of many mRNAs but of the 588 examined, only one, namely monocyte chemotactic protein-1 (MCP-1), showed a decrease on treatment with EGF. A combination of image grabbing followed by subtractive densitometry enabled identification of the mRNAs upregulated in proliferating endothelium. In consideration of the possibility of selective vascular targeting, of particular interest was the increase in expression of the mRNA for the cell surface proteins vascular endothelial (VE-) and neural (N-) cadherin and alpha5, alphav, beta1 and beta3 integrins. The alpha5 integrin offers a previously unrecognized opportunity for vascular targeting.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 14517420   Authors: Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R
Exact source Table 2: Differential expression=arrow up
Related gene sets (show 2 gene sets from the same authors)
External links  
Filtered by similarity
Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform HUMAN_SEQ_ACCESSION
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 49 genes
Gene families Categorize these 49 genes by gene family
Show members (show 52 members mapped to 49 genes)
Version history 3.0: Renamed from EGF_HDMEC_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.