Systematic name M16992
Brief description Genes up-regulated in HDMEC cells (microvascular endothelium): proliferating vs quiescent cells.
Full description or abstract Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothelial cells in the proliferative and quiescent state. Cells were stimulated by a combination of known growth factors for these cells including epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and 'endothelial cell growth supplement (ECGS)' either alone or in combination. Analysis showed the expression of many mRNAs but of the 588 examined, only one, namely monocyte chemotactic protein-1 (MCP-1), showed a decrease on treatment with EGF. A combination of image grabbing followed by subtractive densitometry enabled identification of the mRNAs upregulated in proliferating endothelium. In consideration of the possibility of selective vascular targeting, of particular interest was the increase in expression of the mRNA for the cell surface proteins vascular endothelial (VE-) and neural (N-) cadherin and alpha5, alphav, beta1 and beta3 integrins. The alpha5 integrin offers a previously unrecognized opportunity for vascular targeting.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 14517420   Authors: Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R
Exact source Table 2: Differential expression=arrow up
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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Version history 3.0: Renamed from EGF_HDMEC_UP

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