Human Gene Set: ZHU_CMV_8_HR_DN


Standard name ZHU_CMV_8_HR_DN
Systematic name M9806
Brief description Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV
Full description or abstract Mechanistic insights to viral replication and pathogenesis generally have come from the analysis of viral gene products, either by studying their biochemical activities and interactions individually or by creating mutant viruses and analyzing their phenotype. Now it is possible to identify and catalog the host cell genes whose mRNA levels change in response to a pathogen. We have used DNA array technology to monitor the level of approximately 6,600 human mRNAs in uninfected as compared with human cytomegalovirus-infected cells. The level of 258 mRNAs changed by a factor of 4 or more before the onset of viral DNA replication. Several of these mRNAs encode gene products that might play key roles in virus-induced pathogenesis, identifying them as intriguing targets for further study.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 9826724   Authors: Zhu H,Cong JP,Mamtora G,Gingeras T,Shenk T
Exact source Table 1: 8 h D
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.0: Renamed from CMV_8HRS_DN

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