STANDARD_NAME CHOI_ATL_ACUTE_STAGE SYSTEMATIC_NAME M10100 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHOI_ATL_ACUTE_STAGE NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Acute stage-specific genes for adult T cell leukemia (ATL). DESCRIPTION_FULL Adult T-cell leukemia (ATL) is an intractable malignancy of CD4+ T cells that is etiologically associated with infection by human T-cell leukemia virus-type I. Most individuals in the chronic stage of ATL eventually undergo progression to a highly aggressive acute stage. To clarify the mechanism responsible for this stage progression, we isolated CD4+ cells from individuals in the chronic (n=19) or acute (n=22) stages of ATL and subjected them to profiling of gene expression with DNA microarrays containing >44,000 probe sets. Changes in chromosome copy number were also examined for 24 cell specimens with the use of microarrays harboring approximately 50,000 probe sets. Stage-dependent changes in gene expression profile and chromosome copy number were apparent. Furthermore, expression of the gene for MET, a receptor tyrosine kinase for hepatocyte growth factor (HGF), was shown to be specific to the acute stage of ATL, and the plasma concentration of HGF was increased in individuals in either the acute or chronic stage. HGF induced proliferation of a MET-positive ATL cell line, and this effect was blocked by antibodies to HGF. The HGF-MET signaling pathway is thus a potential therapeutic target for ATL. PMID 16909099 GEOID GSE1466 AUTHORS Choi YL,Tsukasaki K,O'Neill MC,Yamada Y,Onimaru Y,Matsumoto K,Ohashi J,Yamashita Y,Tsutsumi S,Kaneda R,Takada S,Aburatani H,Kamihira S,Nakamura T,Tomonaga M,Mano H CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 4S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 203510_at,206140_at,208595_s_at,211532_x_at,214612_x_at,221911_at GENE_SYMBOLS MET,LHX2,MBD1,KIR2DS4,MAGEA3,ETV1 FOUNDER_NAMES