STANDARD_NAME GSE14000_TRANSLATED_RNA_VS_MRNA_4H_LPS_DC_UP SYSTEMATIC_NAME M3328 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE14000_TRANSLATED_RNA_VS_MRNA_4H_LPS_DC_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of polysome bound (translated) mRNA versus total mRNA 4 h after LPS (TLR4 agonist) stimulation. DESCRIPTION_FULL Dendritic cells (DCs) are the sentinels of the mammalian immune system and they undergo a complex maturation process mediated by activation upon pathogen detection. Recent studies described the analysis of activated DCs by transcriptional profiling, but translation regulation was never taken in account. Therefore, the nature of the mRNAs being translated at various stages of DC activation was determined with the help of translational profiling, which is the sucrose gradient fractionation of polysomal-bound mRNAs combined to microarrays analysis. Total and polysomal-bound mRNA populations were compared in immature (0h) and LPS-stimulated (4h and 16h) human monocyte-derived DCs with the help of Affymetrix microarrays. Biostatistical analysis indicated that 296 mRNA molecules are translationally regulated during DC-activation. The most abundant biological process among the regulated mRNAs was protein biosynthesis, indicating the existence of a negative feedback loop regulating translation. Interestingly, a cluster of 17 ribosomal proteins were part of the regulated mRNAs, indicating that translation may be fine-tuned by particular components of the translational machinery. Our observations highlight the importance of translation regulation during the immune response, and may favour the identification of novel gene clusters or protein networks relevant for immunity. Our study also provides information on the possible absence of correlation between gene expression and real protein production in DCs. PMID 19943945 GEOID GSE14000 AUTHORS Ceppi M,Clavarino G,Gatti E,Schmidt EK,de Gassart A,Blankenship D,Ogola G,Banchereau J,Chaussabel D,Pierre P CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE14000_1529_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACAP2,AFG3L2,AGPS,ANAPC4,ARHGEF18,ARHGEF7,ATP6V0A2,BAG3,BUD13,C10orf18,C12orf11,C12orf41,C17orf71,C17orf85,C1GALT1C1,C1orf131,C20orf202,C4orf41,C6orf211,C8orf41,CCAR1,CCDC130,CCDC93,CCDC99,CDK11A,CELA2A,CELF2,CETN2,CNDP2,CNOT2,CPSF2,CRIPAK,CRYZL1,CSRNP2,DBR1,DCAF13,DCP1B,DDX19A,DDX46,DDX52,DHX29,DHX40,DNAJB12,DNAJC8,DPP8,DUSP11,EFHA1,EIF2B5,EIF3J,ELP4,ERCC3,ETFDH,EXOSC10,EXOSC8,FAM108C1,FAM196A,FASTKD1,FASTKD2,FBXO33,FCAMR,FEN1,FKBP3,GCLM,GFM2,GLCCI1,GPKOW,GRK5,GTF3C3,GTPBP4,HECTD1,HEXIM1,HIST1H2BJ,HMGN5,HNRNPD,HNRPDL,HTATSF1,HYLS1,IFT43,INTS8,ISL1,KAT2A,KATNA1,KDM2A,KDM2B,KIAA1524,LANCL2,LBP,LLPH,LONP2,LRRC47,MAP3K7,MCTS1,MED19,MED27,METTL13,MFN1,MKI67IP,MMP10,MOAP1,MON1B,MPHOSPH6,MPHOSPH8,MRFAP1,MRPL45,MRPS18A,MRPS28,MSTO1,MTM1,N6AMT1,NAA35,NASP,NAT1,NDUFAF1,NFATC2IP,NPM1,NSDHL,NSMCE2,NUBP1,NUMB,NUP37,OAT,OXSM,PDCL,PDHX,PDPK1,PEX3,PIK3C3,PMPCB,PMS2L2,POLR2B,PPIG,PPM1D,PPWD1,PRMT3,PRRC1,PSMB1,PSMD1,PTPN11,PTRH2,QTRTD1,RABGGTB,RASA1,RBM28,RBM8A,RIOK1,RIOK2,RNLS,RPAP3,RRP15,RSBN1L,RSC1A1,RUFY1,SART1,SCO1,SCYL3,SEC62,SERBP1,SERPINB5,SHQ1,SLC4A1AP,SMARCA4,SMARCE1,SMC6,SNX2,SUPT16H,TADA1,TCEB3B,TCERG1,TJAP1,TMCO1,TOPBP1,TRAF5,TRIM27,TRNT1,TTC14,UBA2,UEVLD,UIMC1,UPF3B,UPRT,USP2,USP25,USP48,UTP11L,VRK1,WDR4,YARS2,ZBED5,ZC3HC1,ZCCHC11,ZCCHC8,ZFYVE26,ZNF193,ZNF280C,ZNF326,ZNF627,ZNF680,ZNF711,ZNF776,ZSCAN29 GENE_SYMBOLS ACAP2,AFG3L2,AGPS,ANAPC4,ARHGEF18,ARHGEF7,ATP6V0A2,BAG3,BUD13,TASOR2,INTS13,KANSL2,SMG8,NCBP3,C1GALT1C1,C1orf131,C20orf202,TRAPPC11,ARMT1,TTI2,CCAR1,YJU2B,CCDC93,SPDL1,CDK11A,CELA2A,CELF2,CETN2,CNDP2,CNOT2,CPSF2,,CRYZL1,CSRNP2,DBR1,DCAF13,DCP1B,DDX19A,DDX46,DDX52,DHX29,DHX40,DNAJB12,DNAJC8,DPP8,DUSP11,MICU2,EIF2B5,EIF3J,ELP4,ERCC3,ETFDH,EXOSC10,EXOSC8,ABHD17C,INSYN2A,FASTKD1,FASTKD2,FBXO33,FCAMR,FEN1,FKBP3,GCLM,GFM2,GLCCI1,GPKOW,GRK5,GTF3C3,GTPBP4,HECTD1,HEXIM1,H2BC11,HMGN5,HNRNPD,HNRNPDL,HTATSF1,HYLS1,IFT43,INTS8,ISL1,KAT2A,KATNA1,KDM2A,KDM2B,CIP2A,LANCL2,LBP,LLPH,LONP2,LRRC47,MAP3K7,MCTS1,MED19,MED27,METTL13,MFN1,NIFK,MMP10,MOAP1,MON1B,MPHOSPH6,MPHOSPH8,MRFAP1,MRPL45,MRPS18A,MRPS28,MSTO1,MTM1,N6AMT1,NAA35,NASP,NAT1,NDUFAF1,NFATC2IP,NPM1,NSDHL,NSMCE2,NUBP1,NUMB,NUP37,OAT,OXSM,PDCL,PDHX,PDPK1,PEX3,PIK3C3,PMPCB,PMS2P2,POLR2B,PPIG,PPM1D,PPWD1,PRMT3,PRRC1,PSMB1,PSMD1,PTPN11,PTRH2,QTRT2,RABGGTB,RASA1,RBM28,RBM8A,RIOK1,RIOK2,RNLS,RPAP3,RRP15,RSBN1L,RSC1A1,RUFY1,SART1,SCO1,SCYL3,SEC62,SERBP1,SERPINB5,SHQ1,SLC4A1AP,SMARCA4,SMARCE1,SMC6,SNX2,SUPT16H,TADA1,ELOA2,TCERG1,TJAP1,TMCO1,TOPBP1,TRAF5,TRIM27,TRNT1,TTC14,UBA2,UEVLD,UIMC1,UPF3B,UPRT,USP2,USP25,USP48,UTP11,VRK1,WDR4,YARS2,ZBED5,ZC3HC1,TUT4,ZCCHC8,ZFYVE26,ZSCAN9,ZNF280C,ZNF326,ZNF627,ZNF680,ZNF711,ZNF776,ZSCAN29 FOUNDER_NAMES