STANDARD_NAME GSE15215_CD2_POS_VS_NEG_PDC_DN SYSTEMATIC_NAME M3521 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE15215_CD2_POS_VS_NEG_PDC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of CD2+ plasmacytoid dendritic cells (DC) versus CD2- cells. DESCRIPTION_FULL Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete IFN-alpha and express Granzyme B and TRAIL. CD2high pDCs uniquely express lysozyme and can be found in tonsils and in tumors. Both subsets launch recall T cell response. However, CD2high pDCs secrete higher levels of IL12 p40, express higher levels of co-stimulatory molecule CD80 and are more efficient in triggering proliferation of naïve allogeneic T cells. Thus, human blood pDCs are composed of subsets with specific phenotype and functions. PMID 19454677 GEOID GSE15215 AUTHORS Matsui T,Connolly JE,Michnevitz M,Chaussabel D,Yu CI,Glaser C,Tindle S,Pypaert M,Freitas H,Piqueras B,Banchereau J,Palucka AK CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE15215_1537_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACN9,ACYP1,AFTPH,AIFM1,AKAP9,AP1G1,ARHGAP19,ARHGEF7,ARIH2,ATMIN,ATP2A1,BAG5,BET1,BIN2,BRWD1,BST2,BTN2A1,C11orf48,C12orf47,C13orf18,C1orf27,C21orf91,C2CD2,C2orf3,C6orf120,CA2,CAPZB,CCDC19,CDC123,CDYL,CEP135,CHPF2,CLMN,CLTC,COBLL1,COQ6,COQ9,CREB3,CSTF3,CYP2R1,DBI,DCAF11,DCP1A,DDX50,DHX8,DLG1,DNAJB4,EBP,ELAVL1,ELMO2,ENO1,ENSA,ERAP2,ERGIC3,ETV3,EXOSC9,FAM48A,FAM98A,FBP1,FBXW4,FECH,GABPA,GADD45B,GFI1,GIMAP6,GLUD2,GOLGA4,GORASP1,GOT1,GSN,GTF2H1,HAUS6,HCG9,HERPUD1,HIRA,ID1,IDI1,IGBP1,IL10RB,IRF7,ITM2C,JTB,KANK1,KCTD5,KIAA0494,KIF24,LAPTM5,LCAT,LMBR1L,LMBRD1,LMNB2,LRRC42,MAGEB3,MAGED1,MAPK14,MFF,MOCS2,MRPL15,MRPL28,MRPS22,MRPS7,MTF1,MUL1,MYH3,NAE1,NAGLU,NCK1,NEK1,NEK3,NELL1,NFKB1,NMI,NPC2,ODC1,PAN2,PAPD7,PARP6,PCM1,PCNT,PECAM1,PHB,PHF17,PIK3CA,PIKFYVE,POGK,POLR2B,PPP2R5A,PPP2R5C,PRKCD,PRKCH,PSENEN,PSMA6,PSMD6,PSMG2,PTEN,PTP4A1,RALY,RANBP1,RAP1B,RARS,RBMS1,RHOA,RNF139,RPL3,RPLP1,RPP14,RPS16,RTN3,SC5DL,SCPEP1,SCRN1,SDHA,SELT,SEMA4D,SERTAD3,SF3B1,SHQ1,SLC9A6,SMPD3,SNX6,SRSF10,STAT3,STX4,TAF5L,TAF7L,TAX1BP1,TBC1D8,TBL1XR1,TEX2,TFB1M,TFRC,TGDS,THAP11,TLR7,TMEM109,TMEM41B,TMEM50B,TMEM70,TNKS,TNKS2,TRAF2,TRAPPC10,TUBG2,UBE2H,UBE2L6,UCK2,UGP2,USP15,USP39,UTP11L,VAMP5,VPS39,WDR26,WDR37,ZCCHC11,ZDHHC17,ZDHHC24,ZFC3H1,ZFP64,ZNF394 GENE_SYMBOLS SDHAF3,ACYP1,AFTPH,AIFM1,AKAP9,AP1G1,ARHGAP19,ARHGEF7,ARIH2,ATMIN,ATP2A1,BAG5,BET1,BIN2,BRWD1,BST2,BTN2A1,LBHD1,MAPKAPK5-AS1,RUBCNL,ODR4,C21orf91,C2CD2,GCFC2,C6orf120,CA2,CAPZB,CFAP45,CDC123,CDYL,CEP135,CHPF2,CLMN,CLTC,COBLL1,COQ6,COQ9,CREB3,CSTF3,CYP2R1,DBI,DCAF11,DCP1A,DDX50,DHX8,DLG1,DNAJB4,EBP,ELAVL1,ELMO2,ENO1,ENSA,ERAP2,ERGIC3,ETV3,EXOSC9,SUPT20H,FAM98A,FBP1,FBXW4,FECH,GABPA,GADD45B,GFI1,GIMAP6,GLUD2,GOLGA4,GORASP1,GOT1,GSN,GTF2H1,HAUS6,HCG9,HERPUD1,HIRA,ID1,IDI1,IGBP1,IL10RB,IRF7,ITM2C,JTB,KANK1,KCTD5,EFCAB14,KIF24,LAPTM5,LCAT,LMBR1L,LMBRD1,LMNB2,LRRC42,MAGEB3,MAGED1,MAPK14,MFF,MOCS2,MRPL15,MRPL28,MRPS22,MRPS7,MTF1,MUL1,MYH3,NAE1,NAGLU,NCK1,NEK1,NEK3,NELL1,NFKB1,NMI,NPC2,ODC1,PAN2,TENT4A,PARP6,PCM1,PCNT,PECAM1,PHB1,JADE1,PIK3CA,PIKFYVE,POGK,POLR2B,PPP2R5A,PPP2R5C,PRKCD,PRKCH,PSENEN,PSMA6,PSMD6,PSMG2,PTEN,PTP4A1,RALY,RANBP1,RAP1B,RARS1,RBMS1,RHOA,RNF139,RPL3,RPLP1,RPP14,RPS16,RTN3,SC5D,SCPEP1,SCRN1,SDHA,SELENOT,SEMA4D,SERTAD3,SF3B1,SHQ1,SLC9A6,SMPD3,SNX6,SRSF10,STAT3,STX4,TAF5L,TAF7L,TAX1BP1,TBC1D8,TBL1XR1,TEX2,TFB1M,TFRC,TGDS,THAP11,TLR7,TMEM109,TMEM41B,TMEM50B,TMEM70,TNKS,TNKS2,TRAF2,TRAPPC10,TUBG2,UBE2H,UBE2L6,UCK2,UGP2,USP15,USP39,UTP11,VAMP5,VPS39,WDR26,WDR37,TUT4,ZDHHC17,ZDHHC24,ZFC3H1,ZFP64,ZNF394 FOUNDER_NAMES