STANDARD_NAME GSE18893_CTRL_VS_TNF_TREATED_TREG_2H_DN SYSTEMATIC_NAME M7303 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE18893_CTRL_VS_TNF_TREATED_TREG_2H_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in T reg cells (2h): medium versus TNF [GeneID=7124]. DESCRIPTION_FULL Here we show that tumor necrosis factor (TNF) induced in human T-regulatory cells (Treg), as compared to conventional T cells (Tcon), a transcription program highly enriched for typical NF-κB target genes, such as: the cytokines LTA and TNF; the TNF-receptor super family members FAS, 4-1BB and OX-40; various anti-apoptotic genes; and other important immune-response genes. As an initial approach to examine the cellular program induced by TNF in Tregs versus Tcon cells, we employed microarray gene expression analysis at 2 and 24 hrs following TNF treatment. PMID 20181891 GEOID GSE18893 AUTHORS Nagar M,Jacob-Hirsch J,Vernitsky H,Berkun Y,Ben-Horin S,Amariglio N,Bank I,Kloog Y,Rechavi G,Goldstein I CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE18893_1276_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS A4GALT,AATK,ACOT2,ACTN2,ADRB3,AGT,AIF1,ANKRD13D,AP3M2,ARAP1,ARF1,ARID5A,ARNTL2,ARRB1,ARRDC4,ATP6V0D1,AVPR2,BANK1,BATF2,BTN1A1,C10orf114,C11orf71,C12orf57,C16orf72,C5orf42,C5orf51,C7orf63,C9orf142,C9orf21,CADPS,CCL13,CCNO,CCT8L2,CD180,CD3E,CD97,CD99,CDK17,CLCN7,CMYA5,CNTN2,CPT2,CSF1,DDO,DEPDC1B,DIO3OS,DYNC1I2,EGR3,ELF4,ESM1,EVX1,EXD1,EXOC1,FAF2,FAM161A,FAM163B,FAM168A,FAM188A,FAM53C,FAM83F,FAM8A1,FBXO10,FGF4,FNDC3B,FRAT1,FURIN,FUT7,GAD1,GAK,GALC,GPR75,GPR98,HAS2,HEATR7A,HERC6,HES3,HEY1,HGD,HSF5,HSPB9,HTR1D,IL2RA,IRF2,ITCH,ITK,ITPR2,KCNE1L,KIAA1199,KLC1,KLF3,KLHDC8B,KRTAP15-1,LAMP1,LENG9,LHX5,LMAN2L,LSM14A,MAF1,MAN2A1,MAP1LC3B,MARCH6,MARK4,MED11,MFSD6L,MGST1,MLL5,MLPH,MORN1,MPP2,MUC5B,MYH9,MYO1A,MYO1C,NAMPT,NAT8L,NECAP1,NFAT5,NIPAL2,NKIRAS2,NPHS2,NUDT7,OPN1SW,ORAI1,OTOR,P2RX1,PGM2,PID1,PIGZ,PLA2G5,PLEKHG3,PPOX,PRICKLE3,PROCA1,PRR14,PRSS42,PXK,RAB37,RALBP1,RANBP9,RARA,RBM18,RBM38,RGP1,RHOG,RNF183,RNF38,RNPEP,ROM1,RSAD2,S1PR1,SCAMP2,SEPN1,SERPINB1,SERPINH1,SHFM1,SIRT2,SIRT7,SLC30A3,SMURF1,SNX32,SPATA6,SPG11,SPRY3,SPSB1,SQSTM1,ST3GAL4,STC1,STX6,SV2A,SYT7,TAAR1,TF,TIFAB,TMC4,TMCO3,TMEM41B,TMEM61,TMEM63B,TMEM92,TRAPPC6B,TRIM5,TRPC4,TRPM1,UBE2B,UBL4B,UBR5,UBTD1,UCKL1,USP47,VAMP4,VHL,WEE2,YKT6,ZBTB7B,ZFP36L1,ZNF236,ZNF319,ZNF536,ZNF784,ZP3 GENE_SYMBOLS A4GALT,AATK,ACOT2,ACTN2,ADRB3,AGT,AIF1,ANKRD13D,AP3M2,ARAP1,ARF1,ARID5A,BMAL2,ARRB1,ARRDC4,ATP6V0D1,AVPR2,BANK1,BATF2,BTN1A1,MIR1915HG,C11orf71,C12orf57,HAPSTR1,CPLANE1,RIMOC1,CFAP69,PAXX,PRXL2C,CADPS,CCL13,CCNO,CCT8L2,CD180,CD3E,ADGRE5,CD99,CDK17,CLCN7,CMYA5,CNTN2,CPT2,CSF1,DDO,DEPDC1B,DIO3OS,DYNC1I2,EGR3,ELF4,ESM1,EVX1,EXD1,EXOC1,FAF2,FAM161A,FAM163B,FAM168A,MINDY3,FAM53C,FAM83F,FAM8A1,FBXO10,FGF4,FNDC3B,FRAT1,FURIN,FUT7,GAD1,GAK,GALC,GPR75,ADGRV1,HAS2,MROH1,HERC6,HES3,HEY1,HGD,HSF5,HSPB9,HTR1D,IL2RA,IRF2,ITCH,ITK,ITPR2,KCNE5,CEMIP,KLC1,KLF3,KLHDC8B,KRTAP15-1,LAMP1,LENG9,LHX5,LMAN2L,LSM14A,MAF1,MAN2A1,MAP1LC3B,MARCHF6,MARK4,MED11,MFSD6L,MGST1,KMT2E,MLPH,MORN1,MPP2,MUC5B,MYH9,MYO1A,MYO1C,NAMPT,NAT8L,NECAP1,NFAT5,NIPAL2,NKIRAS2,NPHS2,NUDT7,OPN1SW,ORAI1,OTOR,P2RX1,PGM2,PID1,PIGZ,PLA2G5,PLEKHG3,PPOX,PRICKLE3,PROCA1,PRR14,PRSS42P,PXK,RAB37,RALBP1,RANBP9,RARA,RBM18,RBM38,RGP1,RHOG,RNF183,RNF38,RNPEP,ROM1,RSAD2,S1PR1,SCAMP2,SELENON,SERPINB1,SERPINH1,SEM1,SIRT2,SIRT7,SLC30A3,SMURF1,SNX32,SPATA6,SPG11,SPRY3,SPSB1,SQSTM1,ST3GAL4,STC1,STX6,SV2A,SYT7,TAAR1,TF,TIFAB,TMC4,TMCO3,TMEM41B,TMEM61,TMEM63B,TMEM92,TRAPPC6B,TRIM5,TRPC4,TRPM1,UBE2B,UBL4B,UBR5,UBTD1,UCKL1,USP47,VAMP4,VHL,WEE2,YKT6,ZBTB7B,ZFP36L1,ZNF236,ZNF319,ZNF536,ZNF784,ZP3 FOUNDER_NAMES