STANDARD_NAME GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP SYSTEMATIC_NAME M8272 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE21063_CTRL_VS_ANTI_IGM_STIM_BCELL_NFATC1_KO_8H_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h. DESCRIPTION_FULL Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ flux and proliferation of splenic B cells, increased apoptosis and suppressed germinal centre formation and immunoglobulin class switch by T cell-independent antigens. By controlling IL-10 synthesis in B cells, NFATc1 supported the proliferation and IL-2 synthesis of T cells in vitro and appeared to contribute to the mild clinical course of Experimental Autoimmune Encephalomyelitis in mice bearing NFATc1-/- B cells. These data indicate NFATc1 as a key factor controlling B cell function. PMID 21464221 GEOID GSE21063 AUTHORS Bhattacharyya S,Deb J,Patra AK,Thuy Pham DA,Chen W,Vaeth M,Berberich-Siebelt F,Klein-Hessling S,Lamperti ED,Reifenberg K,Jellusova J,Schweizer A,Nitschke L,Leich E,Rosenwald A,Brunner C,Engelmann S,Bommhardt U,Avots A,Müller MR,Kondo E,Serfling E CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE21063_3436_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCB1,ACSL1,AGFG1,AIM1,ALK,ANKRD13D,ARFGEF2,ARHGEF7,ARID5A,ARNTL,ASB6,ATG2A,ATP2B1,B7H6,BACH2,BAMBI,BCL6,BCL9L,BCOR,BRD1,C14orf43,C1orf115,C20orf108,C20orf112,C21orf2,C21orf96,C22orf37,CACNA2D2,CAMK2N1,CARNS1,CCDC93,CCNL2,CDK12,CHD1,CHD7,CHKA,CKAP4,CLCF1,CNOT6L,COG3,COL6A2,CRTC2,CRY2,CTRL,CTSO,CXorf65,CYTH3,DCTN6,DDI2,DDR2,DDX6,DHX36,DNAJC3,DNMBP,DNTTIP2,DUSP10,DUSP2,EID3,ELL,ENC1,ENTPD4,EPC1,EPHA4,ERO1LB,ETV3,FAM102A,FAM160A2,FAM177A1,FAM53B,FAM83G,FBXL20,FBXO21,FGF9,FOSB,FOXO3,GALNT11,GGA3,GNL1,GPATCH8,GPR65,GTF3C4,HCP5P10,HERC1,HOOK1,HSPA13,IBA57,IDI1,IER5L,IFNGR1,IKZF5,IL18BP,IL7R,ITGA5,ITPKB,ITPRIP,JHDM1D,KDM6B,KIAA2018,KLF3,LOC100130744,LOC100133660,LOC100190986,LOC100289246,LOC152024,LOC400590,LOC727820,LONRF3,LTBP4,LUZP1,LYPD3,LYZ,MAP2K7,MAP3K2,MAPKAPK2,MIA3,MID2,MIDN,MIR101-1,MLL4,MLNR,MLXIP,MMP9,MSL2,MXD4,MYST3,NBEAL2,NFE2L2,NIPBL,NR1D2,NRIP3,OSBPL5,OSBPL7,PDE4B,PDP1,PELI2,PER1,PHLDB3,PIAS2,PIK3CA,PIK3IP1,PIK3R1,PLK3,POFUT2,PSME4,PTP4A1,PTPRE,RAB30,RABGEF1,RAPGEF2,RB1CC1,RBM38,RBMS2,RC3H1,REL,REXO1,RINT1,RNF125,RNF38,RPS6KB1,RSC1A1,RYK,SC5DL,SERTAD1,SETD2,SFN,SGK3,SIRT1,SLC11A2,SMAD7,SMAGP,SMURF1,SMURF2,SNX30,SPEN,SPON2,STX1A,SYAP1,TBC1D23,TCF7L2,TGFB1,TMEM57,TMEM88,TNRC6A,TOPORS,TP53BP2,TRIM39,TRIM52,TSC22D2,TSPYL2,UBL3,WDR91,YPEL5,ZBTB10,ZBTB11,ZBTB2,ZC3H12A,ZFP36,ZFYVE28,ZNF276,ZRANB1 GENE_SYMBOLS ABCB1,ACSL1,AGFG1,CRYBG1,ALK,ANKRD13D,ARFGEF2,ARHGEF7,ARID5A,BMAL1,ASB6,ATG2A,ATP2B1,,BACH2,BAMBI,BCL6,BCL9L,BCOR,BRD1,MIDEAS,C1orf115,FAM210B,NOL4L,CFAP410,,LINC00528,CACNA2D2,CAMK2N1,CARNS1,CCDC93,CCNL2,CDK12,CHD1,CHD7,CHKA,CKAP4,CLCF1,CNOT6L,COG3,COL6A2,CRTC2,CRY2,CTRL,CTSO,CXorf65,CYTH3,DCTN6,DDI2,DDR2,DDX6,DHX36,DNAJC3,DNMBP,DNTTIP2,DUSP10,DUSP2,EID3,ELL,ENC1,ENTPD4,EPC1,EPHA4,ERO1B,ETV3,EEIG1,FHIP1B,FAM177A1,FAM53B,FAM83G,FBXL20,FBXO21,FGF9,FOSB,FOXO3,GALNT11,GGA3,GNL1,GPATCH8,GPR65,GTF3C4,HCP5B,HERC1,HOOK1,HSPA13,IBA57,IDI1,IER5L,IFNGR1,IKZF5,IL18BP,IL7R,ITGA5,ITPKB,ITPRIP,KDM7A,KDM6B,USF3,KLF3,,,,,LINC00691,,,LONRF3,LTBP4,LUZP1,LYPD3,LYZ,MAP2K7,MAP3K2,MAPKAPK2,MIA3,MID2,MIDN,MIR101-1,KMT2D,MLNR,MLXIP,MMP9,MSL2,MXD4,KAT6A,NBEAL2,NFE2L2,NIPBL,NR1D2,NRIP3,OSBPL5,OSBPL7,PDE4B,PDP1,PELI2,PER1,PHLDB3,PIAS2,PIK3CA,PIK3IP1,PIK3R1,PLK3,POFUT2,PSME4,PTP4A1,PTPRE,RAB30,RABGEF1,RAPGEF2,RB1CC1,RBM38,RBMS2,RC3H1,REL,REXO1,RINT1,RNF125,RNF38,RPS6KB1,RSC1A1,RYK,SC5D,SERTAD1,SETD2,SFN,SGK3,SIRT1,SLC11A2,SMAD7,SMAGP,SMURF1,SMURF2,SNX30,SPEN,SPON2,STX1A,SYAP1,TBC1D23,TCF7L2,TGFB1,MACO1,TMEM88,TNRC6A,TOPORS,TP53BP2,TRIM39,TRIM52,TSC22D2,TSPYL2,UBL3,WDR91,YPEL5,ZBTB10,ZBTB11,ZBTB2,ZC3H12A,ZFP36,ZFYVE28,ZNF276,ZRANB1 FOUNDER_NAMES