STANDARD_NAME GSE22313_HEALTHY_VS_SLE_MOUSE_CD4_TCELL_UP SYSTEMATIC_NAME M8586 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE22313_HEALTHY_VS_SLE_MOUSE_CD4_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in CD4 [GeneID=920] T cells: healthy versus systemic lupus erythematosus (SLE). DESCRIPTION_FULL Sle1a.1 is part of the Sle1a lupus susceptibility locus which results in the production of activated and autoreactive CD4+ T cells as well as a reduction in the peripheral regulatory T cell (Treg) pool. Sle1a.1 CD4+ T cells showed a defective response to retinoic acid (RA) expansion of TGFβ-induced Tregs. At the molecular level, Sle1a.1 corresponds to an increased expression of a novel splice isoform of Pbx1, Pbx1-d. Pbx1-d over-expression is sufficient to induce an activated/inflammatory phenotype in Jurkat T cells, and to decrease their apoptotic response to RA. PBX1-d is expressed more frequently in lupus patients than in healthy controls, and its presence correlates with an increased memory T cell population. These findings indicate that Pbx1 is a novel lupus susceptibility gene that regulates T cell activation and tolerance. PMID 22180614 GEOID GSE22313 AUTHORS Cuda CM,Li S,Liang S,Yin Y,Potula HH,Xu Z,Sengupta M,Chen Y,Butfiloski E,Baker H,Chang LJ,Dozmorov I,Sobel ES,Morel L CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE22313_3102_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG2,ABHD5,ACADVL,ADAMTSL4,ADPGK,ADRB3,AGPAT2,AGPAT4,AICDA,ALPK2,ANKK1,ANKLE2,AP2M1,ATP6V0A2,B3GALT5,BAIAP2L2,BATF3,BAX,BCAR3,BMP6,BSX,C10orf99,C1orf220,C6orf168,C7orf50,C7orf70,C9orf37,CBS,CC2D1B,CCDC29,CCDC48,CCDC90A,CCDC92,CCL18,CD274,CD44,CDAN1,CEBPB,CELP,CENPV,CHST7,CISH,CLDN1,CLN3,CMTM4,CXorf36,CYB5A,CYGB,CYTH1,DAG1,DMBX1,DMRTB1,EBF2,ECHDC3,EEFSEC,EFCAB5,EIF4A1,ELF4,ERI1,FABP4,FADS3,FAM100A,FAM110B,FAM3A,FAM59B,FAM86DP,FAM89A,FTH1P5,FZD7,G6PD,GIT1,GPR12,GPR146,GRIN3B,GSK3A,HCAR2,HCAR3,HSPC072,IL11,INF2,INO80B,JUN,JUND,KCND2,KCNE1,KIAA1045,KIAA1919,KIR3DX1,LGALS3,LOC100128988,LOC284023,LRP4,LYRM1,LYSMD1,LZTS2,MAOA,MARCH9,ME3,MFHAS1,MGAT1,MICALL1,MIR487A,MMP24,MSC,MTMR11,NAGPA,NCR3,NFATC2IP,NLGN2,NPC1,NUDT16,NUDT16P1,OCRL,OR52M1,OR8H3,PARP12,PCBD1,PCDHB3,PCOLCE2,PCYT2,PDXK,PECR,PELI3,PEX11A,PHLDA1,PIM3,PITRM1,PLCH1,PLIN2,PM20D1,POFUT2,PPAP2B,PPARG,PPP1R14A,PPP1R15B,ProSAPiP1,PSORS1C3,PTPRE,RARA,RGL3,RNF122,RNF149,RNF157,RNF24,RPS2P45,RRAD,RRP1,RSPH3,RUNDC2C,SCARNA8,SDC2,SDC4,SEPHS2,SEPT3,SEPT4,SERINC2,SGCE,SGK223,SHANK3,SIK2,SIRT5,SLC10A3,SLC16A5,SLC22A5,SLC26A6,SLC35E3,SLC39A11,SLC4A3,SLC6A16,SMG7,SMOC1,SNORA68,SOCS1,SPATS2L,SPIRE2,SPNS1,SVIL,SYT17,TLE1,TMEM111,TMEM120B,TMEM140,TMEM186,TMEM74,TMEM95,TNIP1,TTC39B,UBE2Z,UQCRH,VLDLR,VSTM4,WFDC1,WFDC3,WFS1,WIZ,WNT5A,ZBTB47,ZFYVE26,ZNF417,ZNF646 GENE_SYMBOLS ABCG2,ABHD5,ACADVL,ADAMTSL4,ADPGK,ADRB3,AGPAT2,AGPAT4,AICDA,ALPK2,ANKK1,ANKLE2,AP2M1,ATP6V0A2,B3GALT5,BAIAP2L2,BATF3,BAX,BCAR3,BMP6,BSX,GPR15LG,C1orf220,FAXC,C7orf50,FAM220A,ARRDC1-AS1,CBS,CC2D1B,,EFCC1,MCUR1,CCDC92,CCL18,CD274,CD44,CDAN1,CEBPB,CELP,CENPV,CHST7,CISH,CLDN1,CLN3,CMTM4,DIPK2B,CYB5A,CYGB,CYTH1,DAG1,DMBX1,DMRTB1,EBF2,ECHDC3,EEFSEC,EFCAB5,EIF4A1,ELF4,ERI1,FABP4,FADS3,UBALD1,FAM110B,FAM3A,GAREM2,FAM86DP,FAM89A,FTH1P5,FZD7,G6PD,GIT1,GPR12,GPR146,GRIN3B,GSK3A,HCAR2,HCAR3,LINC00652,IL11,INF2,INO80B,JUN,JUND,KCND2,KCNE1,PHF24,MFSD4B,KIR3DX1,LGALS3,,RNF227,LRP4,LYRM1,LYSMD1,LZTS2,MAOA,MARCHF9,ME3,MFHAS1,MGAT1,MICALL1,MIR487A,MMP24,MSC,MTMR11,NAGPA,NCR3,NFATC2IP,NLGN2,NPC1,NUDT16,NUDT16L2P,OCRL,OR52M1,OR8H3,PARP12,PCBD1,PCDHB3,PCOLCE2,PCYT2,PDXK,PECR,PELI3,PEX11A,PHLDA1,PIM3,PITRM1,PLCH1,PLIN2,PM20D1,POFUT2,PLPP3,PPARG,PPP1R14A,PPP1R15B,PSORS1C3,PTPRE,LZTS3,RARA,RGL3,RNF122,RNF149,RNF157,RNF24,RPS2P45,RRAD,RRP1,RSPH3,SNX29P2,SCARNA8,SDC2,SDC4,SEPHS2,SEPTIN3,SEPTIN4,SERINC2,SGCE,,SHANK3,SIK2,SIRT5,SLC10A3,SLC16A5,SLC22A5,SLC26A6,SLC35E3,SLC39A11,SLC4A3,SLC6A16,SMG7,SMOC1,SNORA68,SOCS1,SPATS2L,SPIRE2,SPNS1,SVIL,SYT17,TLE1,EMC3,TMEM120B,TMEM140,TMEM186,TMEM74,TMEM95,TNIP1,TTC39B,UBE2Z,UQCRH,VLDLR,VSTM4,WFDC1,WFDC3,WFS1,WIZ,WNT5A,ZBTB47,ZFYVE26,ZNF417,ZNF646 FOUNDER_NAMES