STANDARD_NAME GSE22935_UNSTIM_VS_48H_MBOVIS_BCG_STIM_MACROPHAGE_DN SYSTEMATIC_NAME M7779 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE22935_UNSTIM_VS_48H_MBOVIS_BCG_STIM_MACROPHAGE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in macrophages: untreated versus 48h after M. bovis BCG infection. DESCRIPTION_FULL Nitric oxide (NO) produced by macrophages (MØs) is toxic to both host tissues and invading pathogens and its regulation is therefore essential to suppress host cytotoxicity. MØ arginase 1 (Arg1) inhibits NO production by competing with NO synthases for arginine, the common substrate of NO synthases and arginases. Two signal transduction pathways control Arg1 expression in MØs. First, a MyD88-dependent pathway induces Arg1 in intracellular infections, while a second Stat6-dependent pathway is required for Arg1 expression in alternativelyactivated MØs. We found that mycobacteria-infected MØs produce soluble factors that induce Arg1 in an autocrine-paracrine manner via Stat3. We identify these factors as IL-6, IL-10 and GCSF. We further establish that Arg1 expression is controlled by the MyD88-dependent production of IL-6, IL-10 and G-CSF rather than cell intrinsic MyD88 signaling to Arg1. Our data reveal the MyD88-dependent pathway of Arg1induction following BCG infection requires Stat3 activation and may result in the development of an immunosuppressive niche in granulomas due to the induced Arg1 production in surrounding uninfected MØs PMID 20716764 GEOID GSE22935 AUTHORS Qualls JE,Neale G,Smith AM,Koo MS,DeFreitas AA,Zhang H,Kaplan G,Watowich SS,Murray PJ CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE22935_2877_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG1,ACTR1A,ADAL,AKAP2,ARHGAP10,ARHGAP17,ARL8B,ASAP2,ASB13,ATP6V0D1,B3GNT5,BAI1,BAIAP3,BBS2,BDKRB1,BEND5,BLCAP,C10orf90,C11orf70,C16orf89,C16orf95,C17orf91,C19orf38,C19orf47,C5orf30,C6orf106,CACNB4,CAPN10,CBLN2,CBX4,CC2D1B,CD2,CD247,CD74,CECR2,CITED4,CLOCK,CNTN6,COG5,COL9A3,CPA3,CPEB2,CPNE3,CRHR2,CRIP1,CSAD,CSRNP2,CTSG,CTSS,DCLK2,DIAPH2,DR1,DSE,DSP,DYRK1A,ECM1,EIF4G2,ENG,ERAS,ETV5,ETV6,FAM105B,FAM120A,FAM159B,FBXO7,FGFR1,FLVCR1,FOXRED1,FRY,GBP2,GDF2,GFPT1,GPATCH3,GPR15,GPR35,GPR65,GSTO1,HIST2H3C,HNRNPF,HPS5,HSPBAP1,IBTK,IL1R2,IL22,IL6R,INF2,INTS1,IQCB1,ITPRIP,KATNA1,KCTD12,KIAA0232,KIAA1191,KIAA1217,KIF5B,KIT,L1CAM,LAMP2,LEMD3,LETM1,LGMN,LRIG1,LRP5,LRRC58,LSAMP,LTA,MAGED1,MAP2K4,MAPRE2,MARCH7,MGAT4B,MIOX,MTFP1,MXD1,NCKAP1,NIPA2,NMI,NRP2,NRSN2,NYX,OSBPL5,OSGIN2,OTX2,P2RX1,PAG1,PAPSS2,PDCD2,PDZRN3,PIK3CB,PINX1,PLUNC,POGZ,POM121L12,PPM1L,PRKAB1,PROCR,PTCH1,PTGFRN,PTP4A2,RAB3IP,RAGE,RCBTB1,REL,RGMB,RHOG,RNASE6,RND2,RNF112,RNF24,RPL10,RPS16,RRAGD,RUNX3,SCIN,SH3RF3,SHC1,SIK2,SIX5,SLC1A7,SLC26A10,SLC35E2B,SLC37A2,SMNDC1,SMR3A,SNX5,SPAG16,SPG7,SPSB3,SPTAN1,SRPRB,STARD10,STK16,STK19,STK38L,STX1A,TAGLN,TAL1,TBCCD1,TGIF1,THBS1,TMEM140,TPSG1,TPT1,TRAF4,TRIM59,TSC22D2,TSGA10,TSTD2,UBC,VAC14,VPS4A,WARS,WRN,YOD1,YPEL2,ZBTB17,ZDHHC24,ZFYVE26,ZNF347,ZUFSP GENE_SYMBOLS ABCG1,ACTR1A,ADAL,,ARHGAP10,ARHGAP17,ARL8B,ASAP2,ASB13,ATP6V0D1,B3GNT5,ADGRB1,BAIAP3,BBS2,BDKRB1,BEND5,BLCAP,C10orf90,CFAP300,C16orf89,C16orf95,MIR22HG,C19orf38,C19orf47,MACIR,ILRUN,CACNB4,CAPN10,CBLN2,CBX4,CC2D1B,CD2,CD247,CD74,CECR2,CITED4,CLOCK,CNTN6,COG5,COL9A3,CPA3,CPEB2,CPNE3,CRHR2,CRIP1,CSAD,CSRNP2,CTSG,CTSS,DCLK2,DIAPH2,DR1,DSE,DSP,DYRK1A,ECM1,EIF4G2,ENG,ERAS,ETV5,ETV6,OTULIN,FAM120A,SHISAL2B,FBXO7,FGFR1,FLVCR1,FOXRED1,FRY,GBP2,GDF2,GFPT1,GPATCH3,GPR15,GPR35,GPR65,GSTO1,H3C14,HNRNPF,HPS5,HSPBAP1,IBTK,IL1R2,IL22,IL6R,INF2,INTS1,IQCB1,ITPRIP,KATNA1,KCTD12,KIAA0232,KIAA1191,KIAA1217,KIF5B,KIT,L1CAM,LAMP2,LEMD3,LETM1,LGMN,LRIG1,LRP5,LRRC58,LSAMP,LTA,MAGED1,MAP2K4,MAPRE2,MARCHF7,MGAT4B,MIOX,MTFP1,MXD1,NCKAP1,NIPA2,NMI,NRP2,NRSN2,NYX,OSBPL5,OSGIN2,OTX2,P2RX1,PAG1,PAPSS2,PDCD2,PDZRN3,PIK3CB,PINX1,BPIFA1,POGZ,POM121L12,PPM1L,PRKAB1,PROCR,PTCH1,PTGFRN,PTP4A2,RAB3IP,MOK,RCBTB1,REL,RGMB,RHOG,RNASE6,RND2,RNF112,RNF24,RPL10,RPS16,RRAGD,RUNX3,SCIN,SH3RF3,SHC1,SIK2,SIX5,SLC1A7,SLC26A10P,SLC35E2B,SLC37A2,SMNDC1,SMR3A,SNX5,SPAG16,SPG7,SPSB3,SPTAN1,SRPRB,STARD10,STK16,STK19,STK38L,STX1A,TAGLN,TAL1,TBCCD1,TGIF1,THBS1,TMEM140,TPSG1,TPT1,TRAF4,TRIM59,TSC22D2,TSGA10,TSTD2,UBC,VAC14,VPS4A,WARS1,WRN,YOD1,YPEL2,ZBTB17,ZDHHC24,ZFYVE26,ZNF347,ZUP1 FOUNDER_NAMES