STANDARD_NAME GSE23321_CD8_STEM_CELL_MEMORY_VS_NAIVE_CD8_TCELL_DN SYSTEMATIC_NAME M8441 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE23321_CD8_STEM_CELL_MEMORY_VS_NAIVE_CD8_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD8 T cells: stem cell memory versus naïve. DESCRIPTION_FULL An early-differentiated CD8+ memory T cell subset with stem cell-like properties (TSCM) can be identified within the naïve-like T cell population by the expression of CD95/Fas. Based on experiments including exon- and gene-level expression analysis, we provide evidence that this subset of antigen-specific cells represents an early precursor of conventional central (TCM) and effector (TEM) memory CD8+ T cells with enhanced self-renewal capacity and proliferative potential. We identified 900 genes differentially expressed between major T cell subsets defined along with memory T cell commitment. Based on the analysis of these genes, CD95+ naïve T cells (TSCM) cluster closer to the CD8+ T memory compartment than to classical (CD95-) naïve T (TN) cells, and display an intermittent phenotype between classical TN and TCM cells in terms of all major T cell differentiation markers analyzed. PMID 21926977 GEOID GSE23321 AUTHORS Gattinoni L,Lugli E,Ji Y,Pos Z,Paulos CM,Quigley MF,Almeida JR,Gostick E,Yu Z,Carpenito C,Wang E,Douek DC,Price DA,June CH,Marincola FM,Roederer M,Restifo NP CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE23321_2647_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC5,ABHD14A,ABR,ABTB1,AIDA,ALKBH6,ALKBH7,ANGEL2,ANKRD32,AP1G2,ARL2,ASAH1,ASXL2,ATAD2,ATG2A,ATMIN,B3GALT4,B3GNT1,BCAS3,BTN3A1,BTN3A2,BTN3A3,C14orf159,C1orf38,C21orf33,C6orf130,C9orf103,C9orf119,CABIN1,CAP1,CBR4,CBX5,CCDC109B,CCDC77,CCPG1,CD99L2,CDS2,CEP19,CEP192,CGGBP1,CHST12,CISD2,CNPPD1,CRIPAK,CSK,DECR1,DENND1C,DNAJB2,DNASE1L1,DUT,DYNC1LI2,DYRK1A,ECT2,EDEM2,ELMOD2,EPB41,ERMP1,FAM102A,FAM111A,FAM134C,FAM190B,FAM45A,FAM8A1,FANCM,FBXL17,FUK,GALNT3,GMPR2,GNB5,GSDMB,GTF2A1,HEATR5A,HEATR5B,HEBP2,HELQ,HMGB2,HNRNPUL1,HSPA1L,IFFO1,IFIH1,IFT74,INO80E,IRAK4,IRF3,ITGA4,KIAA1530,KIAA2013,KIF11,KLRAQ1,LAIR1,LBR,LETMD1,LOC100289019,LOC282997,LOC284926,LOC286272,LOC646870,LRIG2,LRP10,LYPLAL1,MAN1A2,MAN1B1,MAP4K2,MARCH8,MAX,MDM1,MED25,MEIR5,METTL15,MFSD1,MGAT4A,MOAP1,MOBKL2A,MON1B,NCKAP1L,NCRNA00201,NCRNA00324,NDC80,NF1,NMT2,NUDT16L1,OAS1,OSTF1,PAN3,PAQR8,PASK,PCNT,PDE3B,PDE4A,PDE6D,PGPEP1,PHF15,PHKB,PINK1,PPOX,PRIM1,PRMT2,PRORSD1P,RABGAP1L,RAC2,RALBP1,RBL1,RCOR3,RGS14,RNASEL,RNF187,RNF214,RPRD1A,RPS27L,RPS6KA5,SAC3D1,SIDT2,SLC30A6,SLC38A6,SNRPN,SNX18,SP4,SPG11,SSH2,STUB1,SYTL1,TACC3,TADA3,TAOK1,TAS2R14,TBC1D22A,TET1,TGOLN2,TMEM134,TMEM154,TMEM179B,TMEM218,TMEM219,TMEM59,TMEM9B,TNKS,TNRC6B,TPK1,TRIM38,TSNAX,TTC15,TTC18,UBA7,UBAC1,UQCR10,VPS11,VPS24,VPS52,WAS,XRN1,YIPF1,ZFAND2B,ZFP62,ZFYVE26,ZFYVE28,ZNF217,ZNF33A,ZNF673,ZSCAN16,ZZEF1 GENE_SYMBOLS ABCC5,ABHD14A,ABR,ABTB1,AIDA,ALKBH6,ALKBH7,ANGEL2,SLF1,AP1G2,ARL2,ASAH1,ASXL2,ATAD2,ATG2A,ATMIN,B3GALT4,B3GNT2,BCAS3,BTN3A1,BTN3A2,BTN3A3,DGLUCY,THEMIS2,GATD3,OARD1,IDNK,SWI5,CABIN1,CAP1,CBR4,CBX5,MCUB,CCDC77,CCPG1,CD99L2,CDS2,CEP19,CEP192,CGGBP1,CHST12,CISD2,CNPPD1,,CSK,DECR1,DENND1C,DNAJB2,DNASE1L1,DUT,DYNC1LI2,DYRK1A,ECT2,EDEM2,ELMOD2,EPB41,ERMP1,EEIG1,FAM111A,RETREG3,CCSER2,DENND10,FAM8A1,FANCM,FBXL17,FCSK,GALNT3,GMPR2,GNB5,GSDMB,GTF2A1,HEATR5A,HEATR5B,HEBP2,HELQ,HMGB2,HNRNPUL1,HSPA1L,IFFO1,IFIH1,IFT74,INO80E,IRAK4,IRF3,ITGA4,UVSSA,KIAA2013,KIF11,PPP1R21,LAIR1,LBR,LETMD1,SLC25A25-AS1,PDCD4-AS1,,,,LRIG2,LRP10,LYPLAL1,MAN1A2,MAN1B1,MAP4K2,MARCHF8,MAX,MDM1,MED25,SFR1,METTL15,MFSD1,MGAT4A,MOAP1,MOB3A,MON1B,NCKAP1L,HNRNPU,LINC00324,NDC80,NF1,NMT2,NUDT16L1,OAS1,OSTF1,PAN3,PAQR8,PASK,PCNT,PDE3B,PDE4A,PDE6D,PGPEP1,JADE2,PHKB,PINK1,PPOX,PRIM1,PRMT2,PRORSD1P,RABGAP1L,RAC2,RALBP1,RBL1,RCOR3,RGS14,RNASEL,RNF187,RNF214,RPRD1A,RPS27L,RPS6KA5,SAC3D1,SIDT2,SLC30A6,SLC38A6,SNRPN,SNX18,SP4,SPG11,SSH2,STUB1,SYTL1,TACC3,TADA3,TAOK1,TAS2R14,TBC1D22A,TET1,TGOLN2,TMEM134,TMEM154,TMEM179B,TMEM218,TMEM219,TMEM59,TMEM9B,TNKS,TNRC6B,TPK1,TRIM38,TSNAX,TRAPPC12,CFAP70,UBA7,UBAC1,UQCR10,VPS11,CHMP3,VPS52,WAS,XRN1,YIPF1,ZFAND2B,ZFP62,ZFYVE26,ZFYVE28,ZNF217,ZNF33A,KRBOX4,ZSCAN16,ZZEF1 FOUNDER_NAMES