STANDARD_NAME GSE25677_MPL_VS_R848_STIM_BCELL_UP SYSTEMATIC_NAME M8186 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE25677_MPL_VS_R848_STIM_BCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in B lymphocytes after immunization with: monophosphoryl lipid A versus imiquimod [PubChem=13982876]. DESCRIPTION_FULL Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence suggests that activate dendritic cells (DCs) via Toll-like receptors (TLRs). For example, the yellow fever vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates DCs via multiple TLRs to stimulate pro-inflammatory cytokines. Triggering specific combinations of TLRs in DCs can induce synergistic production of cytokines, which results in enhanced T cell responses, but its impact on antibody responses remain unknown. Learning the critical parameters of innate immunity that programs such antibody responses remains a major challenge in vaccinology. We demonstrated that immunization of mice with synthetic nanoparticles containing antigens plus Toll-like receptor (TLR) ligands 4 (MPL) + 7 (R837) induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with a single TLR ligand. To determine whether there was any early programming of B cells, we isolated isotype switched, TCRbeta-CD11b-CD19+IgD-IgG+ B cells by FACS at 7 days post immunization with nanoparticles containing various adjuvants plus OVA, and performed microarray analyses to assess their molecular signatures. PMID 21350488 GEOID GSE25677 AUTHORS Kasturi SP,Skountzou I,Albrecht RA,Koutsonanos D,Hua T,Nakaya HI,Ravindran R,Stewart S,Alam M,Kwissa M,Villinger F,Murthy N,Steel J,Jacob J,Hogan RJ,GarcĂ­a-Sastre A,Compans R,Pulendran B CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE25677_1567_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1500011K16Rik,1700048O20Rik,1700106N22Rik,2010001M09Rik,2310044G17Rik,5830405N20Rik,9030617O03Rik,A530040E14Rik,ABCB1A,ABCG3,ABHD5,ABR,ACBD4,ADRBK2,AI452195,AI848100,ALPL,ARHGAP24,ARHGEF12,AS3MT,ASB2,ASNS,ATP6V1G2,ATXN1,AY036118,BCAP29,BCAR3,BID,BLK,BLNK,BZW2,CACNA1E,CARS2,CCBP2,CCDC79,CCR1,CD180,CD1D1,CD1D2,CD274,CD300LF,CD36,CD38,CD81,CD86,CD9,CDC42BPB,CDH17,CEACAM2,COPG2,CR2,CREBL2,CSF2RB,CXCR7,CYBB,CYFIP1,CYP39A1,DCLRE1C,DLL3,DPH5,DRAM2,DSE,DTX1,DUSP16,EDEM1,ELL3,EMX2,ERO1L,FAM129C,FAM92A,FBXO9,FCRL5,FFAR2,FMNL3,FUCA1,FUCA2,GBP8,GM10673,GM10786,GM12000,GM2A,GM6377,GM7265,GNS,GOLIM4,GPR156,GRAMD1B,GRN,HCK,HERC3,HES5,HMGN3,HSPA5,I830077J02Rik,ID2,IKZF1,IL9R,INPP5F,ITGAL,ITPR2,KCNK5,LAIR1,LILRB4,LOC100046496,LPCAT2,LRRC16A,LY6A,LY6K,LYNX1,MARCKS,MATK,MCOLN3,MICAL3,MS4A1,MS4A14,MTNR1A,MYC,MYCBP2,MYL4,MYOF,NAB1,NDST1,NEBL,NEDD4,NRP2,PDCD4,PDE4D,PDE8A,PDLIM2,PER3,PGC,PHXR4,PIK3R4,PIP4K2A,PKD1,PKIB,PLA2G7,PLAC8,PLBD1,PLD4,PLEKHA1,PLXNC1,PLXND1,PPL,PRDM1,PRKDC,PSAP,PSMD14,PTK2,PTPN14,PTPN18,PTPRJ,RASGEF1B,RBM47,RGS10,RILPL2,RNF219,RNFT2,RPS20,RPS9,RRBP1,RUFY3,RUNDC3B,RXFP1,S1PR1,SCD2,SEMA7A,SH3KBP1,SLC29A3,SLC38A9,SLC39A6,SLC9A9,SORBS2,SRGAP3,TAF1D,TBC1D9,TBL1XR1,TCF4,TLR3,TLR7,TMEM131,TMEM26,TMTC4,TNFRSF18,TRAF1,TRIM32,TRPM2,TSGA13,TSPAN15,TUBG2,TYROBP,UBE2E2,UBE2R2,UTRN,UXS1,WDR11,ZC3H12C,ZDHHC14,ZFP532,ZKSCAN1 GENE_SYMBOLS ,,,,,,,,,,ABHD5,ABR,ACBD4,GRK3,PDE4D,SUCO,ALPL,ARHGAP24,ARHGEF12,AS3MT,ASB2,ASNS,ATP6V1G2,ATXN1,,BCAP29,BCAR3,BID,BLK,BLNK,BZW2,CACNA1E,CARS2,ACKR2,TERB1,CCR1,CD180,,,CD274,CD300LF,CD36,CD38,CD81,CD86,CD9,CDC42BPB,CDH17,,COPG2,CR2,CREBL2,CSF2RB,ACKR3,CYBB,CYFIP1,CYP39A1,DCLRE1C,DLL3,DPH5,DRAM2,DSE,DTX1,DUSP16,EDEM1,ELL3,EMX2,ERO1A,NIBAN3,CIBAR1,FBXO9,FCRL5,FFAR2,FMNL3,FUCA1,FUCA2,,,,,GM2A,,,GNS,GOLIM4,GPR156,GRAMD1B,GRN,HCK,HERC3,HES5,HMGN3,HSPA5,,ID2,IKZF1,IL9R,INPP5F,ITGAL,ITPR2,KCNK5,LAIR1,LILRB4,,LPCAT2,CARMIL1,LY6S,LY6K,LYNX1,MARCKS,MATK,MCOLN3,MICAL3,MS4A1,MS4A14,MTNR1A,MYC,MYCBP2,MYL4,MYOF,NAB1,NDST1,NEBL,NEDD4,NRP2,PDCD4,PDE4D,PDE8A,PDLIM2,PER3,PGC,,PIK3R4,PIP4K2A,PKD1,PKIB,PLA2G7,PLAC8,PLBD1,PLD4,PLEKHA1,PLXNC1,PLXND1,PPL,PRDM1,PRKDC,PSAP,PSMD14,PTK2,PTPN14,PTPN18,PTPRJ,RASGEF1B,RBM47,RGS10,RILPL2,OBI1,RNFT2,RPS20,RPS9,RRBP1,RUFY3,RUNDC3B,RXFP1,S1PR1,,SEMA7A,SH3KBP1,SLC29A3,SLC38A9,SLC39A6,SLC9A9,SORBS2,SRGAP3,TAF1D,TBC1D9,TBL1XR1,TCF4,TLR3,TLR7,TMEM131,TMEM26,TMTC4,TNFRSF18,TRAF1,TRIM32,TRPM2,TSGA13,TSPAN15,TUBG2,TYROBP,UBE2E2,UBE2R2,UTRN,UXS1,WDR11,ZC3H12C,ZDHHC14,,ZKSCAN1 FOUNDER_NAMES