STANDARD_NAME GSE30083_SP2_VS_SP4_THYMOCYTE_DN SYSTEMATIC_NAME M5035 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE30083_SP2_VS_SP4_THYMOCYTE_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in comparison of SP2 thymocytes versus SP4 thymocytes. DESCRIPTION_FULL After positive selection in the thymus, the newly generated single positive (SP) thymocytes are phenotypically and functionally immature and undergo apoptosis upon antigen stimulation. In the thymic medullary microenvironment, SP cells progressively acquire immunocompetence. Negative selection to remove autoreactive T cells also occur at this stage. We have defined four subsets of CD4 SP, namely, SP1, SP2, SP3, and SP4 that follow a functional maturation program and a sequential emergence during mouse ontogeny.We used microarray to detail the global programm of gene expression during the maturation of murine CD4 single positive thymocytes PMID 22022412 GEOID GSE30083 AUTHORS Teng F,Zhou Y,Jin R,Chen Y,Pei X,Liu Y,Dong J,Wang W,Pang X,Qian X,Chen WF,Zhang Y,Ge Q CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE30083_2164_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACADL,ACSBG1,ADAMTS20,ADCY7,AGAP2,AHNAK,AIM2,ALS2CL,AMIGO2,ANKH,AP1G2,APP,APPL2,AQP3,ARSB,ATP10D,ATP8B4,B4GALNT4,BPNT1,BTBD11,C19orf12,C1orf130,C22orf13,C5,CASP1,CCDC102A,CCDC88C,CCND1,CCR2,CD38,CD68,CD97,CDH1,CDIPT,CLCF1,CLEC10A,CORO2A,COX6A2,CREBL2,CRLF3,CTSH,CTSS,CXCR3,CXorf21,CYBASC3,CYBB,CYP4V2,CYTH4,DAAM1,DAND5,DAPL1,DAXX,DNAH8,DNAJB13,DPH5,DPP4,DSE,EHBP1L1,ENDOD1,EVI2B,F2RL1,FAM101B,FAM129A,FAM167A,FAM18B1,FAM43A,FAM46A,FAM46C,FAM65B,FAM69A,FAM78A,FCGR2A,FGL2,GABRR2,GALNT9,GEM,GIMAP5,GM2A,GNA15,GOLM1,GPR114,GPR68,GRN,HAVCR1,HEATR7A,HHEX,HIBADH,HLA-B,HOPX,HPSE,HS3ST3B1,HVCN1,IBA57,IER5,IFI44,IFIT1,IFIT3,IFITM10,IFNG,IFNGR1,IGFBP4,IL17RA,IL18R1,IL2RB,INADL,IPCEF1,IRF8,ITGA4,ITGA6,ITGAE,KCNN2,KHK,KLF3,KLHDC1,KLHDC2,LAIR1,LDLRAP1,LIF,LY75,LY86,MADD,MAF,MAN1C1,MAP3K5,MCTP2,MLL,MPEG1,MPP4,MS4A6A,MX2,N4BP2L1,NCF4,NOD1,NRP1,NT5E,NTRK3,NXT2,OAS1,PDE3B,PDLIM4,PEA15,PHYHD1,PLEK,PNPLA7,PPM1J,PPP3CC,PQLC3,PRG4,RAB21,RASA3,RHOB,RHOQ,RIN2,RNF144A,RNF32,RRM2B,S1PR1,S1PR4,SCFD1,SDC4,SDCBP2,SELPLG,SGK1,SHCBP1L,SIDT1,SKAP2,SLAMF6,SLC17A9,SLC35A3,SLC41A2,SMPDL3A,SNTB2,SNX10,SOCS3,SPN,ST14,ST8SIA6,STAT4,SUCLG2,SYNE2,TAP1,TASP1,TBX21,TF,TJP2,TK2,TLR1,TMEM150B,TMEM71,TP63,TRAF5,TRPM6,TTC39B,TTC39C,UPB1,VDR,XDH,ZBTB16,ZBTB25,ZNF536 GENE_SYMBOLS ACADL,ACSBG1,ADAMTS20,ADCY7,AGAP2,AHNAK,AIM2,ALS2CL,AMIGO2,ANKH,AP1G2,APP,APPL2,AQP3,ARSB,ATP10D,ATP8B4,B4GALNT4,BPNT1,ABTB3,C19orf12,NCMAP,GUCD1,C5,CASP1,CCDC102A,CCDC88C,CCND1,CCR2,CD38,CD68,ADGRE5,CDH1,CDIPT,CLCF1,CLEC10A,CORO2A,COX6A2,CREBL2,CRLF3,CTSH,CTSS,CXCR3,TASL,CYB561A3,CYBB,CYP4V2,CYTH4,DAAM1,DAND5,DAPL1,DAXX,DNAH8,DNAJB13,DPH5,DPP4,DSE,EHBP1L1,ENDOD1,EVI2B,F2RL1,RFLNB,NIBAN1,FAM167A,TVP23B,FAM43A,TENT5A,TENT5C,RIPOR2,DIPK1A,FAM78A,FCGR2A,FGL2,GABRR2,GALNT9,GEM,GIMAP5,GM2A,GNA15,GOLM1,ADGRG5,GPR68,GRN,HAVCR1,MROH1,HHEX,HIBADH,HLA-B,HOPX,HPSE,HS3ST3B1,HVCN1,IBA57,IER5,IFI44,IFIT1,IFIT3,IFITM10,IFNG,IFNGR1,IGFBP4,IL17RA,IL18R1,IL2RB,PATJ,IPCEF1,IRF8,ITGA4,ITGA6,ITGAE,KCNN2,KHK,KLF3,KLHDC1,KLHDC2,LAIR1,LDLRAP1,LIF,LY75,LY86,MADD,MAF,MAN1C1,MAP3K5,MCTP2,KMT2A,MPEG1,MPP4,MS4A6A,MX2,N4BP2L1,NCF4,NOD1,NRP1,NT5E,NTRK3,NXT2,OAS1,PDE3B,PDLIM4,PEA15,PHYHD1,PLEK,PNPLA7,PPM1J,PPP3CC,SLC66A3,PRG4,RAB21,RASA3,RHOB,RHOQ,RIN2,RNF144A,RNF32,RRM2B,S1PR1,S1PR4,SCFD1,SDC4,SDCBP2,SELPLG,SGK1,SHCBP1L,SIDT1,SKAP2,SLAMF6,SLC17A9,SLC35A3,SLC41A2,SMPDL3A,SNTB2,SNX10,SOCS3,SPN,ST14,ST8SIA6,STAT4,SUCLG2,SYNE2,TAP1,TASP1,TBX21,TF,TJP2,TK2,TLR1,TMEM150B,TMEM71,TP63,TRAF5,TRPM6,TTC39B,TTC39C,UPB1,VDR,XDH,ZBTB16,ZBTB25,ZNF536 FOUNDER_NAMES