STANDARD_NAME GSE42088_UNINF_VS_LEISHMANIA_INF_DC_8H_DN SYSTEMATIC_NAME M9910 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE42088_UNINF_VS_LEISHMANIA_INF_DC_8H_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in dendritic cells: untreated versus 8h after infection of Leishmania major. DESCRIPTION_FULL Leishmania major infected human dendritic cells (DCs) exhibit a marked induction of IL-12 ultimately promoting a robust Th1-mediated response associated with parasite killing and protective immunity. In this study, we utilized Affymetrix Genechips to globally assess the host cell genes and pathways associated with L. major infection during early infection (2, 4, 8, and 24 hrs) in human myeloid-derived DCs. Bioinformatic analyses of the hybridized microarray chips identified 728 genes, represented by 848 unique probe sets, which, when compared to uninfected samples were observed to be significantly differentially expressed by one-way ANOVA. Altogether, the data provide a genome-wide perspective on the transcriptional influences Leishmania species exert within human DCs during early infection, and provides a platform for further investigations toward functionally characterizing candidate genes of importance to the IL-12 based immune response to infections. In the current study, we further investigate the L. major infected DC transcriptional during early time points after infection via microarray analysis. PMID 24808365 GEOID GSE42088 AUTHORS Favila MA,Geraci NS,Zeng E,Harker B,Condon D,Cotton RN,Jayakumar A,Tripathi V,McDowell MA CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE42088_3825_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCC2,ABCD2,ADPGK,AIRE,ALOX5,AMMECR1,AMOT,ANKRD26,AOC2,APBB1,ARL15,ARSB,ASB9,ATP1A3,ATP9B,B3GALT1,BAIAP2,BMP15,BMPR1B,C20orf12,C20orf7,C2orf83,CACNA1G,CAMK2G,CD207,CDH6,CDK20,CEP164,CHAF1A,CIITA,CLCN3,COL10A1,CREB5,CRYBG3,CSN1S1,CTGF,CUEDC1,CXCR7,CYP2A7,DEFA6,DGKE,DHTKD1,DST,DYM,DYNC2LI1,ERBB3,ETAA1,F11R,FAM192A,FAM53C,FAM55C,FBXO22,FHOD3,FN1,GABRA3,GPATCH2,GPHN,GPR162,GPR63,GPR64,GPX1,GRAMD1C,GRM7,GULP1,H2AFY,HAP1,HIF3A,HIST1H3C,HPS1,HS2ST1,IFNA21,IFNGR1,IL10RA,IL3,IL33,IL36A,IRF6,KCNJ6,KCNMB3,KDM4A,KIAA1598,KIF15,KIR3DX1,KRT4,LAMA1,LDHAL6B,LIMD1,LOC100287008,LOC100287076,LOC57399,LOC728142,LRP1B,LRP2BP,MAGEA4,MAGEC3,MAPK9,MAPT,MCM10,MECOM,MEIS2,MEPE,MTMR12,MTUS1,NAA16,NAV3,NBAS,NBEA,NEB,NEUROD1,NFIC,NINL,NPC2,NPIPL2,NPY2R,NSUN7,NTSR1,NUAK1,P2RX2,PAK6,PARD6B,PARK2,PARP2,PART1,PCDHGC3,PCLO,PCYOX1,PDE6A,PEAK1,PECAM1,PFKFB4,PHC1,PIP5K1B,PKNOX2,PLD2,PLS1,POLA1,PRRG3,PSAP,PSG5,PTH,PTPLA,PYY,RAB33B,RARRES2,REPIN1,RGS17,RGS3,RHOT1,ROBO4,RPE,RRAGB,RUSC1,SCRN3,SEPT11,SERPINF1,SLC25A14,SLC25A31,SLC30A6,SLC4A10,SLC9A3,SLCO4C1,SLFN12,SNCAIP,SNTB2,SOD3,SPO11,SSX3,ST18,SYNPO2L,SYT1,TACSTD2,TMEM19,TMLHE,TNFRSF11A,TPP1,TRAM2,TRDMT1,TRIL,TRIP13,TSGA14,UEVLD,UNC5C,USP6,VAT1,VPREB3,VPS52,WHSC1L1,WNT7A,WWTR1,YLPM1,ZFYVE26,ZNF167,ZNF180,ZNF253,ZNF304,ZNF391,ZNF41,ZNF43,ZNF682,ZNF93 GENE_SYMBOLS ABCC2,ABCD2,ADPGK,AIRE,ALOX5,AMMECR1,AMOT,ANKRD26,AOC2,APBB1,ARL15,ARSB,ASB9,ATP1A3,ATP9B,B3GALT1,BAIAP2,BMP15,BMPR1B,DZANK1,NDUFAF5,C2orf83,CACNA1G,CAMK2G,CD207,CDH6,CDK20,CEP164,CHAF1A,CIITA,CLCN3,COL10A1,CREB5,CRYBG3,CSN1S1,CCN2,CUEDC1,ACKR3,CYP2A7,DEFA6,DGKE,DHTKD1,DST,DYM,DYNC2LI1,ERBB3,ETAA1,F11R,PSME3IP1,FAM53C,NXPE3,FBXO22,FHOD3,FN1,GABRA3,GPATCH2,GPHN,GPR162,GPR63,ADGRG2,GPX1,GRAMD1C,GRM7,GULP1,MACROH2A1,HAP1,HIF3A,H3C3,HPS1,HS2ST1,IFNA21,IFNGR1,IL10RA,IL3,IL33,IL36A,IRF6,KCNJ6,KCNMB3,KDM4A,SHTN1,KIF15,KIR3DX1,KRT4,LAMA1,LDHAL6B,LIMD1,,,,MED14OS,LRP1B,LRP2BP,MAGEA4,MAGEC3,MAPK9,MAPT,MCM10,MECOM,MEIS2,MEPE,MTMR12,MTUS1,NAA16,NAV3,NBAS,NBEA,NEB,NEUROD1,NFIC,NINL,NPC2,NPIPB15,NPY2R,NSUN7,NTSR1,NUAK1,P2RX2,PAK6,PARD6B,PRKN,PARP2,PART1,PCDHGC3,PCLO,PCYOX1,PDE6A,PEAK1,PECAM1,PFKFB4,PHC1,PIP5K1B,PKNOX2,PLD2,PLS1,POLA1,PRRG3,PSAP,PSG5,PTH,HACD1,PYY,RAB33B,RARRES2,REPIN1,RGS17,RGS3,RHOT1,ROBO4,RPE,RRAGB,RUSC1,SCRN3,SEPTIN11,SERPINF1,SLC25A14,SLC25A31,SLC30A6,SLC4A10,SLC9A3,SLCO4C1,SLFN12,SNCAIP,SNTB2,SOD3,SPO11,SSX3,ST18,SYNPO2L,SYT1,TACSTD2,TMEM19,TMLHE,TNFRSF11A,TPP1,TRAM2,TRDMT1,TRIL,TRIP13,CEP41,UEVLD,UNC5C,USP6,VAT1,VPREB3,VPS52,NSD3,WNT7A,WWTR1,YLPM1,ZFYVE26,ZKSCAN7,ZNF180,ZNF253,ZNF304,ZNF391,ZNF41,ZNF43,ZNF682,ZNF93 FOUNDER_NAMES