STANDARD_NAME GSE43863_LY6C_INT_CXCR5POS_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN SYSTEMATIC_NAME M9755 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE43863_LY6C_INT_CXCR5POS_VS_LY6C_LOW_CXCR5NEG_EFFECTOR_CD4_TCELL_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Ly6c int CXCR5+ [GeneID=643] versus Ly6c low CXCR5- [GeneID=643]. DESCRIPTION_FULL CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transfer of antigen-specific memory CD4+ subpopulations (based on CXCR5 and Ly6c expression)in the LCMV infection model, we found that there are distinct memory CD4+ T cell populations with commitment to the Tfh and Th1 lineages. Our conclusions are based on gene expression profiles, epigenetic studies and phenotypic and functional analysis. The gene expression profiles of virus-specific CD4 T cell subets at effector and memory stages is presented here. PMID 23583644 GEOID GSE43863 AUTHORS Hale JS,Youngblood B,Latner DR,Mohammed AU,Ye L,Akondy RS,Wu T,Iyer SS,Ahmed R CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE43863_3744_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACE2,AGFG1,AHI1,AHR,ALCAM,AMZ2,AP1M2,APOC4,ARC,ATF3,ATN1,ATP6V0B,ATP6V0C,ATP6V0D1,AVPI1,AVPR1B,B4GALT5,BEX1,BLK,BRI3,BTG3,C10orf58,C14orf149,C15orf48,C16orf61,C17orf91,C20orf46,C5orf30,C6orf154,CACNA1B,CASP4,CCNO,CCR6,CDC14B,CENPV,CHKA,CHPF,CHRNA3,CHRNB3,CHST11,CLCN6,CLN3,CMTM2,CMTM6,CNIH,CNTNAP4,CPS1,CRYM,CSRNP1,CST7,CYP2B6,DEGS1,DTX1,DUSP14,DUSP4,DVL1,EEA1,EGR1,EGR2,EMILIN2,EPHB3,F3,FAM126A,FAM178B,FAM189B,FBXW11,FLVCR2,GAA,GABARAP,GCNT1,GFI1,GIT1,GM2A,GMIP,GNG4,GPR65,GRHL1,GRIPAP1,GUCY1B3,HGS,HIC1,HLA-A,HLA-DRA,HLA-DRB1,HOMER2,HSPA5,IER2,IGF2R,IL13RA1,IL15RA,IL1R2,IL2,ITGAV,JAK2,JAM2,KRT71,KRT86,LAG3,LAMP1,LAT2,LCK,LEPROTL1,LGI1,LIPG,LNX2,LRP10,LRRC8C,LY75,MALT1,MAPKAPK3,MDFIC,MRGPRE,MYO1D,MYO1E,NAB2,NDFIP2,NELF,NEO1,NFATC1,NGEF,NR4A2,NR4A3,OTUD7B,PACSIN1,PDXK,PFKP,PIM3,PLAGL1,PLEK,PLK3,PMP22,PPP1R15A,PQLC1,PREX2,PRKCA,PTGER4,PTGES,PTGFR,PTRH1,RAB20,RAB8B,RBPJ,RBPMS2,RENBP,RGS13,RILPL2,RND2,RNH1,ROGDI,RPS6KA2,S1PR3,SAT1,SERPINB1,SERPINB9,SH2D2A,SH3KBP1,SLC15A3,SLC23A3,SLC25A18,SLC29A3,SLC35B1,SLC38A1,SLC3A2,SLC7A1,SLMO1,SPP1,SPRY1,SRGN,ST6GALNAC6,STX3,SULT2B1,SYCE2,SYNGR2,SYNPO,TAGAP,TAS2R1,TBX21,TGFB1,TIPARP,TJP2,TMEFF1,TMEM51,TNFRSF13C,TNFSF14,TNIP2,TOB2,TOX2,TPD52,TPST2,TRIO,TRPS1,TSSK6,TUBB2A,UBASH3B,UHRF1BP1,VEGFB,VEZT,VSX2,XCL1,ZDHHC24 GENE_SYMBOLS ACE2,AGFG1,AHI1,AHR,ALCAM,AMZ2,AP1M2,APOC4,ARC,ATF3,ATN1,ATP6V0B,ATP6V0C,ATP6V0D1,AVPI1,AVPR1B,B4GALT5,BEX1,BLK,BRI3,BTG3,PRXL2A,L3HYPDH,C15orf48,CMC2,MIR22HG,TMEM74B,MACIR,LRRC73,CACNA1B,CASP4,CCNO,CCR6,CDC14B,CENPV,CHKA,CHPF,CHRNA3,CHRNB3,CHST11,CLCN6,CLN3,CMTM2,CMTM6,CNIH1,CNTNAP4,CPS1,CRYM,CSRNP1,CST7,CYP2B6,DEGS1,DTX1,DUSP14,DUSP4,DVL1,EEA1,EGR1,EGR2,EMILIN2,EPHB3,F3,HYCC1,FAM178B,ENTREP3,FBXW11,FLVCR2,GAA,GABARAP,GCNT1,GFI1,GIT1,GM2A,GMIP,GNG4,GPR65,GRHL1,GRIPAP1,GUCY1B1,HGS,HIC1,HLA-A,HLA-DRA,HLA-DRB1,HOMER2,HSPA5,IER2,IGF2R,IL13RA1,IL15RA,IL1R2,IL2,ITGAV,JAK2,JAM2,KRT71,KRT86,LAG3,LAMP1,LAT2,LCK,LEPROTL1,LGI1,LIPG,LNX2,LRP10,LRRC8C,LY75,MALT1,MAPKAPK3,MDFIC,MRGPRE,MYO1D,MYO1E,NAB2,NDFIP2,NSMF,NEO1,NFATC1,NGEF,NR4A2,NR4A3,OTUD7B,PACSIN1,PDXK,PFKP,PIM3,PLAGL1,PLEK,PLK3,PMP22,PPP1R15A,SLC66A2,PREX2,PRKCA,PTGER4,PTGES,PTGFR,PTRH1,RAB20,RAB8B,RBPJ,RBPMS2,RENBP,RGS13,RILPL2,RND2,RNH1,ROGDI,RPS6KA2,S1PR3,SAT1,SERPINB1,SERPINB9,SH2D2A,SH3KBP1,SLC15A3,SLC23A3,SLC25A18,SLC29A3,SLC35B1,SLC38A1,SLC3A2,SLC7A1,PRELID3A,SPP1,SPRY1,SRGN,ST6GALNAC6,STX3,SULT2B1,SYCE2,SYNGR2,SYNPO,TAGAP,TAS2R1,TBX21,TGFB1,TIPARP,TJP2,TMEFF1,TMEM51,TNFRSF13C,TNFSF14,TNIP2,TOB2,TOX2,TPD52,TPST2,TRIO,TRPS1,TSSK6,TUBB2A,UBASH3B,BLTP3A,VEGFB,VEZT,VSX2,XCL1,ZDHHC24 FOUNDER_NAMES