STANDARD_NAME GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_DN SYSTEMATIC_NAME M9700 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE44732_UNSTIM_VS_IL27_STIM_IMATURE_DC_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in immature dendritic cells: untreated versus IL27 [GeneID=246778]. DESCRIPTION_FULL IL-27 treated DCs were shown to be highly potent inhibitors of cis HIV-1, particularly of CCR5 tropic strains. Microarray studies of IL-27 treated DCs showed no up-regulation of Type I (IFN) gene expression. Neutralization of the Type-I IFN receptor had no impact on the HIV inhibition. Lastly, IL-27 mediated inhibition was shown to act post-viral entry and prior to completion of reverse transcription. These results show for the first time that IL-27 is a potent inhibitor of cis HIV-1 infection in DCs by a Type I IFN independent mechanism. PMID 23527130 GEOID GSE44732 AUTHORS Chen Q,Swaminathan S,Yang D,Dai L,Sui H,Yang J,Hornung RL,Wang Y,Huang da W,Hu X,Lempicki RA,Imamichi T CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE44732_3800_200_DN FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCG2,ABHD5,ABHD6,ACSL1,ADAM17,AGAP11,APLP2,APOC1,ATF3,ATP11B,BCCIP,BLVRA,BLVRB,BST1,C11orf45,C12orf4,C19orf59,C1orf112,C20orf30,C2CD3,C3,C3orf71,C6orf64,C9orf156,CABLES1,CALM3,CARD14,CASP9,CCDC56,CD1D,CD300A,CD300LF,CD52,CD68,CD82,CIB1,CORO2A,CR1,CTSA,CTSD,CYBA,DECR1,DENND5A,DISP1,DNAJB11,DNAJC5B,DTX4,DUSP10,EAF2,ECH1,EEPD1,EHF,EIF4EBP2,ENG,EPAS1,EREG,ERGIC3,FAM154B,FAM55C,FAM89A,FCGRT,FGF3,FGR,FHIT,FKBP15,FLVCR2,GABARAPL1,GGA2,GGN,GLTSCR1,GPCPD1,GPR107,GPRIN3,GPS2,GUSB,HEXB,HIVEP2,HNRNPA1L2,HPCAL1,HSD11B1,HSD17B14,IDH1,IFIT2,IFIT3,IFNAR2,IGHA1,IK,IL36B,IL7R,IQGAP2,ITGA3,ITGAE,ITGAL,ITSN1,JAKMIP2,KAZN,KCNAB2,KCNE1,KLHL21,KPTN,KRTCAP3,LAMP1,LBR,LCMT2,LFNG,LIMK2,LMAN2L,LOC100128002,LOC100133109,LOC100287628,LOC100506585,LOC284837,LPCAT3,LPXN,ME3,MECR,MFSD11,MME,MORN2,MRAS,MYL4,NAA20,NANS,NDUFA2,NEU1,NEU3,NHSL1,NLRC4,NR1H3,NUP214,OAS1,PAPSS2,PC,PDIA4,PEX14,PGBD5,PGS1,PHC1,PHLDA3,PIP4K2A,PLBD1,PLCXD1,PLIN2,PNPLA3,POLH,POLR2K,POLR3C,POR,PPAPDC2,PRAM1,PRKCB,PRKCE,PTGS1,RAB20,RAB42,RAD51AP1,RFPL2,RHBDF2,RPS11,RUNX1,S100A8,S100A9,SARDH,SCARNA15,SCCPDH,SEL1L3,SERPINB6,SIGLEC15,SIPA1L2,SLC45A3,SNAI3,SNTB1,SPOCD1,SSR2,STK38,STON2,STX18,TBC1D2,TBL2,TBXAS1,TGFB1,TLR4,TM7SF4,TMED3,TMEM127,TMEM208,TMEM218,TMEM53,TPD52L1,TRMT12,TSC22D1,TTC1,TTC39B,TTC9,TXNDC12,VLDLR,VNN2,VWA5A,WDR73,WFS1 GENE_SYMBOLS ABCG2,ABHD5,ABHD6,ACSL1,ADAM17,AGAP11,APLP2,APOC1,ATF3,ATP11B,BCCIP,BLVRA,BLVRB,BST1,KCNJ5-AS1,C12orf4,MCEMP1,C1orf112,TMEM230,C2CD3,C3,ARIH2OS,SAYSD1,TRMO,CABLES1,CALM3,CARD14,CASP9,COA3,CD1D,CD300A,CD300LF,CD52,CD68,CD82,CIB1,CORO2A,CR1,CTSA,CTSD,CYBA,DECR1,DENND5A,DISP1,DNAJB11,DNAJC5B,DTX4,DUSP10,EAF2,ECH1,EEPD1,EHF,EIF4EBP2,ENG,EPAS1,EREG,ERGIC3,SAXO2,NXPE3,FAM89A,FCGRT,FGF3,FGR,FHIT,FKBP15,FLVCR2,GABARAPL1,GGA2,GGN,BICRA,GPCPD1,GPR107,GPRIN3,GPS2,GUSB,HEXB,HIVEP2,HNRNPA1L2,HPCAL1,HSD11B1,HSD17B14,IDH1,IFIT2,IFIT3,IFNAR2,IGHA1,IK,IL36B,IL7R,IQGAP2,ITGA3,ITGAE,ITGAL,ITSN1,JAKMIP2,KAZN,KCNAB2,KCNE1,KLHL21,KPTN,KRTCAP3,LAMP1,LBR,LCMT2,LFNG,LIMK2,LMAN2L,,,,PTPRN2-AS1,AATBC,LPCAT3,LPXN,ME3,MECR,MFSD11,MME,MORN2,MRAS,MYL4,NAA20,NANS,NDUFA2,NEU1,NEU3,NHSL1,NLRC4,NR1H3,NUP214,OAS1,PAPSS2,PC,PDIA4,PEX14,PGBD5,PGS1,PHC1,PHLDA3,PIP4K2A,PLBD1,PLCXD1,PLIN2,PNPLA3,POLH,POLR2K,POLR3C,POR,PLPP6,PRAM1,PRKCB,PRKCE,PTGS1,RAB20,RAB42,RAD51AP1,RFPL2,RHBDF2,RPS11,RUNX1,S100A8,S100A9,SARDH,SCARNA15,SCCPDH,SEL1L3,SERPINB6,SIGLEC15,SIPA1L2,SLC45A3,SNAI3,SNTB1,SPOCD1,SSR2,STK38,STON2,STX18,TBC1D2,TBL2,TBXAS1,TGFB1,TLR4,DCSTAMP,TMED3,TMEM127,TMEM208,TMEM218,TMEM53,TPD52L1,TRMT12,TSC22D1,TTC1,TTC39B,TTC9,TXNDC12,VLDLR,VNN2,VWA5A,WDR73,WFS1 FOUNDER_NAMES