STANDARD_NAME GSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP SYSTEMATIC_NAME M5657 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE6269_FLU_VS_STREP_PNEUMO_INF_PBMC_UP NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. pneumoniae infection. DESCRIPTION_FULL Each infectious agent represents a unique combination of pathogen-associated molecular patterns that interact with specific pattern-recognition receptors expressed on immune cells. Therefore, we surmised that the blood immune cells of individuals with different infections might bear discriminative transcriptional signatures. Gene expression profiles were obtained for 131 peripheral blood samples from pediatric patients with acute infections caused by influenza A virus, Gram-negative (Escherichia coli) or Gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) bacteria. Thirty-five genes were identified that best discriminate patients with influenza A virus infection from patients with either E coli or S pneumoniae infection. These genes classified with 95% accuracy (35 of 37 samples) an independent set of patients with either influenza A, E coli, or S pneumoniae infection. A different signature discriminated patients with E coli versus S aureus infections with 85% accuracy (34 of 40). Furthermore, distinctive gene expression patterns were observed in patients presenting with respiratory infections of different etiologies. Thus, microarray analyses of patient peripheral blood leukocytes might assist in the differential diagnosis of infectious diseases. PMID 17105821 GEOID GSE6269 AUTHORS Ramilo O,Allman W,Chung W,Mejias A,Ardura M,Glaser C,Wittkowski KM,Piqueras B,Banchereau J,Palucka AK,Chaussabel D CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE6269_1520_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 200003_s_at,200601_at,200616_s_at,200702_s_at,200772_x_at,200887_s_at,200905_x_at,200923_at,200986_at,201015_s_at,201024_x_at,201085_s_at,201119_s_at,201183_s_at,201315_x_at,201544_x_at,201601_x_at,201649_at,201762_s_at,201786_s_at,201793_x_at,201794_s_at,201965_s_at,202086_at,202123_s_at,202145_at,202170_s_at,202269_x_at,202270_at,202412_s_at,202869_at,203067_at,203153_at,203217_s_at,203496_s_at,203593_at,203653_s_at,203882_at,203942_s_at,203964_at,204021_s_at,204047_s_at,204116_at,204170_s_at,204185_x_at,204211_x_at,204224_s_at,204279_at,204402_at,204415_at,204423_at,204439_at,204601_at,204639_at,204728_s_at,204747_at,204972_at,204994_at,205339_at,205483_s_at,205552_s_at,205660_at,205917_at,206133_at,206553_at,206890_at,207186_s_at,207700_s_at,207740_s_at,207966_s_at,208012_x_at,208087_s_at,208436_s_at,208624_s_at,208685_x_at,208710_s_at,208812_x_at,208930_s_at,208965_s_at,208966_x_at,208993_s_at,209003_at,209024_s_at,209060_x_at,209127_s_at,209140_x_at,209417_s_at,209709_s_at,209761_s_at,209762_x_at,209849_s_at,209969_s_at,210005_at,210045_at,210057_at,210479_s_at,210625_s_at,210846_x_at,211012_s_at,211094_s_at,211122_s_at,211352_s_at,212007_at,212027_at,212079_s_at,212178_s_at,212203_x_at,212380_at,212384_at,212487_at,212520_s_at,212587_s_at,212620_at,212649_at,212809_at,212994_at,213043_s_at,213069_at,213109_at,213199_at,213261_at,213293_s_at,213294_at,213322_at,213378_s_at,213383_at,213729_at,213797_at,213803_at,213850_s_at,213932_x_at,213996_at,214022_s_at,214059_at,214315_x_at,214453_s_at,214690_at,214730_s_at,214757_at,214911_s_at,215773_x_at,216526_x_at,216565_x_at,217497_at,217777_s_at,217891_at,217919_s_at,217958_at,218085_at,218135_at,218349_s_at,218397_at,218400_at,218506_x_at,218543_s_at,218564_at,218599_at,218859_s_at,218913_s_at,218927_s_at,218986_s_at,219158_s_at,219209_at,219211_at,219352_at,219519_s_at,219684_at,219863_at,219895_at,220085_at,220315_at,220492_s_at,220925_at,220934_s_at,221683_s_at,221685_s_at,221816_s_at,221875_x_at,222154_s_at,222158_s_at,222175_s_at,222335_at,243_g_at,32069_at,34221_at,36552_at,44673_at,47069_at,51774_s_at,53720_at,58916_at,91952_at,AFFX-HUMISGF3A/M97935_3_at,AFFX-HUMISGF3A/M97935_5_at,AFFX-HUMISGF3A/M97935_MA_at,AFFX-HUMISGF3A/M97935_MB_at,AFFX-HUMRGE/M10098_3_at,AFFX-HUMRGE/M10098_5_at,AFFX-r2-Hs18SrRNA-3_s_at,AFFX-r2-Hs18SrRNA-5_at GENE_SYMBOLS RPL28,ACTN4,MLEC,DDX24,PTMA,STAT1,HLA-E,LGALS3BP,SERPING1,JUP,EIF5B,SON,COX8A,CHD4,IFITM2,PABPN1,IFITM1,UBE2L6,PSME2,ADAR,SMG7,SMG7,SETX,MX1,ABL1,LY6E,AASDHPPT,GBP1,GBP1,USP1,OAS1,PDHX,IFIT1,ST3GAL5,MED1,CD2AP,COIL,IRF9,MARK2,NMI,PURA,PHACTR2,IL2RG,CKS2,PPID,EIF2AK2,GCH1,PSMB9,RHBDD3,IFI6,MKLN1,IFI44L,N4BP1,ADA,WDHD1,IFIT3,OAS2,MX2,STIL,ISG15,OAS1,OASL,ZNF264,XAF1,,IL12RB1,BPTF,NCOA3,NUP62,GLG1,SP110,ZBP1,IRF7,EIF4G1,BRD2,AP3D1,HLA-B,ILF3,IFI16,IFI16,PPIG,SLC25A11,SYNCRIP,NCOA3,SART3,HLA-B,IFI35,HMMR,SP110,SP110,RAD51C,STAT1,GART,IDH2,SMG1,RORA,AKAP1,TRIM14,PML,NF1,CXCL11,NCOA3,UBXN4,RBM25,KMT2A,POM121,IFITM3,CMTR1,DDX39B,GPATCH8,SMARCA4,PTPRC,ZNF609,,NFATC2IP,THOC2,MED24,HEG1,TNIK,C2CD3,TRANK1,TRIM22,EIF2AK2,OARD1,DDX11,SBF1,PRPF40A,RSAD2,KPNB1,SCAF11,HLA-A,YPEL1,IFITM1,IFI44,CALR,IFI44,TAF1B,GLG1,DTX2P1-UPK3BP1-PMS2P11,BRD2,PARP2,HLA-B,IFITM3P7,TYMP,HACD3,RUSF1,MRPL42,TRAPPC4,CHMP5,ERGIC2,ZWILCH,,OAS3,GLYR1,PARP12,RFWD3,REC8,ESF1,GMIP,CHST12,DDX60,NAA15,IFIH1,USP18,HERC6,SIGLEC1,RTP4,HERC5,TMEM255A,HELLS,PARP11,,NAA35,NXF1,CEP290,SPDL1,PHF11,HLA-F,SPATS2L,DESI2,MED15,TGS1,MAP4,N4BP1,HMGXB3,C2CD3,SIGLEC1,PRR5,UBE2D4,SHFL,KCTD14,DCAF15,STAT1,STAT1,STAT1,STAT1,,MIR3648-1,,MIR3648-1 FOUNDER_NAMES