STANDARD_NAME KEGG_LYSOSOME SYSTEMATIC_NAME M11266 COLLECTION C2:CP:KEGG_LEGACY MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/KEGG_LYSOSOME NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF Lysosome DESCRIPTION_FULL Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. PMID GEOID AUTHORS CONTRIBUTOR KEGG CONTRIBUTOR_ORG Kyoto Encyclopedia of Genes and Genomes EXACT_SOURCE hsa04142 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://www.genome.jp/kegg/pathway/hsa/hsa04142.html SOURCE_MEMBERS 10053,10239,10312,10577,10717,1075,10947,11154,1174,1176,1200,1201,1203,1211,1212,1213,130340,138050,1497,1508,1509,1510,1511,1512,1513,1514,1515,1519,1520,1521,1522,162,164,175,1777,20,22901,23062,23163,23431,23457,23545,23659,245972,2517,2548,256471,2581,2588,26088,2629,26503,26985,27074,2717,2720,2760,2799,285362,2990,3073,3074,3373,3423,3425,3482,3916,3920,3988,4074,410,411,4125,4126,427,4668,4669,4758,4864,4891,50617,51172,51606,527,53,533,535,537,54,5476,55353,5538,5641,5660,57192,58511,6272,6448,6556,6609,768239,7805,79158,8120,8218,84572,8546,8722,8763,8905,8907,8943,9114,9179,9374,9476,950,9583,967,968,9741 GENE_SYMBOLS AP1M2,AP3S2,TCIRG1,NPC2,AP4B1,CTSC,AP3M2,AP4S1,AP1S1,AP3S1,TPP1,CLN3,CLN5,CLTA,CLTB,CLTC,AP1S3,HGSNAT,CTNS,CTSB,CTSD,CTSE,CTSG,CTSH,CTSK,CTSL,CTSV,CTSO,CTSS,CTSW,CTSZ,AP1B1,AP1G1,AGA,DNASE2,ABCA2,ARSG,GGA2,GGA3,AP4E1,ABCB9,ATP6V0A2,PLA2G15,ATP6V0D2,FUCA1,GAA,MFSD8,GALC,GALNS,GGA1,GBA1,SLC17A5,AP3M1,LAMP3,GLA,GLB1,GM2A,GNS,SUMF1,GUSB,HEXA,HEXB,HYAL1,IDS,IDUA,IGF2R,LAMP1,LAMP2,LIPA,M6PR,ARSA,ARSB,MAN2B1,MANBA,ASAH1,NAGA,NAGLU,NEU1,NPC1,SLC11A2,ATP6V0A4,NAGPA,ATP6V1H,ATP6V0C,ACP2,ATP6V0B,ATP6V0A1,ATP6AP1,ACP5,CTSA,LAPTM4B,PPT1,LGMN,PSAP,MCOLN1,DNASE2B,SORT1,SGSH,SLC11A1,SMPD1,PSAPL1,LAPTM5,GNPTAB,AP3B2,CLTCL1,GNPTG,AP3B1,CTSF,CD164,AP1S2,AP1M1,AP3D1,ATP6V0D1,AP4M1,PPT2,NAPSA,SCARB2,ENTPD4,CD63,CD68,LAPTM4A FOUNDER_NAMES