STANDARD_NAME MCBRYAN_PUBERTAL_BREAST_3_4WK_DN SYSTEMATIC_NAME M8155 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MCBRYAN_PUBERTAL_BREAST_3_4WK_DN NAMESPACE AFFY_Mouse430 DESCRIPTION_BRIEF Genes down-regulated during pubertal mammary gland development between weeks 3 and 4. DESCRIPTION_FULL Expression microarray analysis identified over 930 genes regulated during puberty in the mouse mammary gland. Most prominent were genes whose expression increased in parallel with pubertal development and remained high thereafter. Members of the Wnt, transforming growth factor-beta and oestrogen-signalling pathways were significantly overrepresented. Comparison to expression data from CITED1 knockout mice identified a subset of oestrogen-responsive genes displaying altered expression in the absence of CITED1. Included in this subset are stanniocalcin2 (Stc2) and amphiregulin (Areg). Chromatin immunoprecipitation revealed that ERalpha binds to oestrogen response elements in both the Stc2 and Areg genes in the mammary gland during puberty. Additionally, CITED1 and ERalpha localize to the same epithelial cells of the pubertal mammary gland, supporting a role for interaction of these two proteins during normal development. In a human breast cancer data set, expression of Stc2, Areg and CITED1 parallel that of ERalpha. Similar to ERalpha, CITED1 expression correlates with good outcome in breast cancer, implying that potential maintenance of the ERalpha-CITED1 co-regulated signalling pathway in breast tumours can indicate good prognosis. PMID 17486082 GEOID GSE6453 AUTHORS McBryan J,Howlin J,Kenny PA,Shioda T,Martin F CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S: week 3 to 4 = D FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1416023_at,1416807_at,1417066_at,1417461_at,1417732_at,1418469_at,1418709_at,1418809_at,1418908_at,1419043_a_at,1419247_at,1419646_a_at,1419821_s_at,1420342_at,1421163_a_at,1421551_s_at,1421818_at,1423062_at,1423506_a_at,1423831_at,1424126_at,1424638_at,1425396_a_at,1426113_x_at,1426159_x_at,1426163_x_at,1426243_at,1426657_s_at,1427050_at,1427329_a_at,1428850_x_at,1429128_x_at,1430128_a_at,1433471_at,1434484_at,1436688_x_at,1438159_x_at,1438654_x_at,1438988_x_at,1439374_x_at,1439415_x_at,1442025_a_at,1448881_at,1450974_at,1451221_at,1451718_at,1452348_s_at,1460555_at GENE_SYMBOLS FABP3,RPL36A,COQ8A,CAP1,ANXA8L1,NRIP1,COX7A1,LILRB3,PAM,,RGS2,MBP,IDH1,,NFIA,,BCL6,IGFBP3,NNAT,PRKAG2,ALAS1,CDKN1A,LCK,TRAC,TRBC2,,CTH,PHGDH,TXNDC16,IGHM,,NFKB2,REEP6,TCF7,WFDC21P,RPL14,NDUFV2,MMD2,JPT1,RPS10,,ZBTB16,HP,TIMP4,ICE1,PLP1,IFI16,RIPOR2 FOUNDER_NAMES