STANDARD_NAME NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_UP SYSTEMATIC_NAME M41008 COLLECTION C7:VAX MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in peripheral blood mononuclear cell 3d vs 0d in adults (18-50) after exposure to FluMist , time point 3D. Comment: Supplementary Table 1b: All the differentially expressed genes identified in PBMCs of TIV vaccinees. DESCRIPTION_FULL Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines. PMID 21743478 GEOID AUTHORS Nakaya HI,Wrammert J,Lee EK,Racioppi L,Marie-Kunze S,Haining WN,Means AR,Kasturi SP,Khan N,Li GM,McCausland M,Kanchan V,Kokko KE,Li S,Elbein R,Mehta AK,Aderem A,Subbarao K,Ahmed R,Pulendran B CONTRIBUTOR HIPC SIGNATURES CONTRIBUTOR_ORG NIAID/HIPC SIGNATURES EXACT_SOURCE Suppl Table 1B, Tab DEGs_LAIV FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140559/bin/NIHMS301940-supplement-2.xlsx SOURCE_MEMBERS AAK1,AAMP,ABCF2,ADAM10,ADAP2,ADRBK2,AFG3L2,AGPAT3,AGPS,AGTRAP,AGXT2L2,AIF1,AIMP2,AK2,AKR1A1,ALDH1A1,ALDH2,ALDH3A2,ALDH9A1,AMN1,ANP32A-IT1,AOAH,AP1S2,AP2A2,AP2S1,AP3D1,APLP2,APOL3,APPL1,ARHGAP17,ARPC1B,ARPC5,ARRB1,ARSD,ASH2L,ASRGL1,ASXL2,ATIC,ATP10D,ATP5H,ATP5J2,ATP6V0D1,ATP6V1A,ATP6V1B2,ATP6V1C1,AURKAIP1,B3GALT6,BANF1,BCKDHA,BLNK,BLVRA,BST2,BTF3L4,BTK,BZW2,C10orf76,C10orf84,C11orf17,C11orf68,C11orf75,C14orf147,C15orf63,C16orf5,C17orf62,C17orf90,C19orf42,C1orf151,C1orf83,C20orf30,C21orf33,C22orf28,C22orf9,C4orf29,C4orf34,C8orf83,CAMKK2,CARD16,CARD9,CASP1,CAST,CBL,CBR1,CCDC50,CCDC56,CD14,CD302,CD36,CD84,CD86,CD93,CDK13,CEBPA,CECR1,CES2,CFP,CHCHD8,CHKB,CHMP4A,CHMP5,CHST15,CHTF8,CIITA,CITED2,CLCN3,CLEC4A,CLN5,CLPTM1,CLTA,CMTM7,CNDP2,CNP,COMMD8,COMT,CORO1C,COX5A,CPNE8,CPVL,CREBL2,CROCC,CROCCL1,CRTAP,CSK,CSNK2A1,CST3,CSTB,CTBP2,CTDSP2,CTNNA1,CTNND1,CTSB,CTSC,CTSS,CUEDC2,CYBASC3,CYBB,CYC1,CYFIP1,CYP4V2,DAPK1,DCAF7,DCTD,DCTN2,DCTPP1,DDOST,DDX18,DDX60,DDX60L,DERA,DMAC1,DMXL1,DNASE2,DNLZ,DPAGT1,DPH3,DPP8,DPYD,DRG1,DTX3L,DYNC1I2,DYNLL1,EAF2,EBNA1BP2,ECHDC1,ECHS1,EFTUD2,EHBP1L1,EIF2AK1,EMILIN2,ENO1,ENY2,EPB41L3,ERCC1,ESRP2,ETFA,EXOC4,EXOSC1,EXOSC5,FAM110A,FAM113B,FAM127A,FAM173A,FAM192A,FAM198B,FAM36A,FAM38A,FAM82B,FAM96A,FASTK,FBP1,FCER1G,FCGR1B,FCN1,FGD2,FGD4,FGL2,FGR,FKBP15,FKBP5,FUCA1,GALNT2,GAS7,GATAD1,GCNT2,GDI2,GEMIN7,GIT2,GIYD2,GLRX,GLYR1,GNS,GOLIM4,GPAA1,GPBAR1,GRN,GRSF1,GSTO1,GSTP1,GTF2H2,GTF2H2C,GTF2H2D,GTF3C2,HAUS7,HCG18,HCK,HDHD1A,HEBP1,HFE,HHEX,HIPK2,HK1,HK3,HLA-DMB,HLA-DRB1,HM13,HMGN4,HNRNPA0,HOXA7,HPSE,HTATIP2,HVCN1,ICE2,IDH2,IDH3A,IDH3G,IFI16,IFI30,IFI35,IFT80,IGHG1,IGHM,IKZF1,IKZF3,IL10RB,IL17RA,ILK,INTS7,IRF5,IRF7,ITPR2,ITPRIPL2,JAK2,KCNE3,KCTD12,KIAA0513,KLHL36,KLHL6,KRTAP2-4,KYNU,LAIR1,LARP1,LARP4B,LARS,LBHD1,LDAH,LEPROT,LILRA1,LILRB1,LIMS1,LMO2,LSM10,LSM6,LTA4H,LY6H,MANF,MAP2K1,MAP4,MAPK1,MARCH1,MARCO,MAT2A,MAT2B,MED16,MEF2C,MEGF9,MESDC2,METTL7A,METTL8,MFSD1,MFSD14B,MGST3,MKKS,MLKL,MLX,MPEG1,MRM2,MRPL16,MRPL20,MRPL24,MRPL51,MRPS11,MRPS16,MRPS18C,MS4A4A,MS4A6A,MX1,MX2,MYCBP,MYD88,MYOF,N4BP2L1,NAAA,NADK,NAGA,NAGK,NAIP,NCOA2,NDUFAF3,NDUFB10,NDUFB3,NDUFB5,NDUFS2,NDUFS7,NECAP2,NIF3L1,NIPAL3,NOLC1,NOTCH2,NSL1,NUB1,NUDT22,NUDT5,NUP214,OAS1,OAS2,OAS3,OCIAD1,OGFOD1,ORAI3,ORMDL2,OSCAR,P,PAICS,PANK2,PARP1,PARP12,PARP14,PCK2,PCMT1,PCMTD1,PDCD6,PDHB,PDIA6,PDLIM5,PDXK,PEA15,PECAM1,PGD,PGLS,PGM2,PHPT1,PIGP,PIK3AP1,PIK3C3,PLAC8,PLBD1,PLOD3,PLSCR1,PLXNB2,PMVK,POLK,PPA2,PPHLN1,PPID,PPP1R11,PPP1R7,PPT1,PRAM1,PRDX4,PRELID1,PREPL,PROSC,PRPF19,PRPF6,PRR5L,PSMB10,PSMB2,PSMB9,PTBP1,PTGER2,PUSL1,PYCARD,QKI,RAB10,RAB27A,RAB3GAP1,RAB40C,RAB4B,RAB8A,RAP1GDS1,RASSF4,RB1,RBBP4,RBM8A,RDH11,REEP4,REEP5,RGS19,RHBDD1,RNF135,RNF20,RNF5,RNFT1,RNH1,RPRD2,RPUSD3,RRP12,RRP7A,RSL1D1,RTN1,RUBCN,RUFY3,RXRA,S100Z,SAMD9L,SAMHD1,SART3,SAT2,SBNO1,SCAMP2,SCARB2,SCPEP1,SDHC,SDR39U1,SEC22B,SEC23IP,SELENOH,SERBP1,SERF2,SERPINB1,SH2D3C,SHMT2,SHTN1,SIDT2,SLC12A7,SLC22A18,SLC24A1,SLC24A4,SLC25A24,SLC27A3,SLC2A6,SLC31A1,SLC7A7,SLX1A,SMARCA4,SMURF2,SNTB2,SNX1,SNX17,SNX2,SNX27,SNX6,SP110,SPTLC1,SPTLC2,SQRDL,SRD5A3,SRGAP2P1,SSB,SSR1,STAT1,STAT2,STX4,STX7,SUCLG1,SULT1A1,SUMF1,SUSD1,SYK,SYNCRIP,SYNE3,SYTL3,TAF4,TANGO2,TBC1D8,TBXAS1,TCF3,TCF4,TCF7L2,TICAM2,TIMM8B,TINF2,TKT,TLR7,TLR8,TM9SF1,TM9SF4,TMBIM4,TMED7-TICAM2,TMED9,TMEM126B,TMEM19,TMEM205,TMEM209,TMEM63A,TMEM80,TMPO,TMX1,TNFSF10,TNFSF12-TNFSF13,TNFSF13,TNFSF13B,TNRC6B,TNS3,TOR1A,TOR1B,TPI1,TPST2,TRAPPC3,TREX1,TRIM14,TRIM22,TRIM34,TRIM5,TRIM6-TRIM34,TRIM69,TRIO,TRIP11,TRMT112,TSPAN31,TSPAN4,UBE2I,UBE2L3,UCP2,UEVLD,UNC50,UNC93B1,USP19,USP34,VAV1,VPS41,VRK2,WSB1,XAF1,XIAP,XRCC5,YWHAB,YWHAE,YY1AP1,ZC3H4,ZFAND5,ZNF106,ZNF143,ZNHIT1 GENE_SYMBOLS AAK1,AAMP,ABCF2,ADAM10,ADAP2,GRK3,AFG3L2,AGPAT3,AGPS,AGTRAP,PHYKPL,AIF1,AIMP2,AK2,AKR1A1,ALDH1A1,ALDH2,ALDH3A2,ALDH9A1,AMN1,,AOAH,AP1S2,AP2A2,AP2S1,AP3D1,APLP2,APOL3,APPL1,ARHGAP17,ARPC1B,ARPC5,ARRB1,ARSD,ASH2L,ASRGL1,ASXL2,ATIC,ATP10D,ATP5PD,ATP5MF,ATP6V0D1,ATP6V1A,ATP6V1B2,ATP6V1C1,AURKAIP1,B3GALT6,BANF1,BCKDHA,BLNK,BLVRA,BST2,BTF3L4,BTK,BZW2,ARMH3,FAM204A,AKIP1,C11orf68,SMCO4,SPTSSA,HYPK,CDIP1,CYBC1,OXLD1,SMIM7,MICOS10,TCEANC2,TMEM230,GATD3,RTCB,KIAA0930,ABHD18,SMIM14,TRIQK,CAMKK2,CARD16,CARD9,CASP1,CAST,CBL,CBR1,CCDC50,COA3,CD14,CD302,CD36,CD84,CD86,CD93,CDK13,CEBPA,ADA2,CES2,CFP,COA4,CHKB,CHMP4A,CHMP5,CHST15,CHTF8,CIITA,CITED2,CLCN3,CLEC4A,CLN5,CLPTM1,CLTA,CMTM7,CNDP2,CNP,COMMD8,COMT,CORO1C,COX5A,CPNE8,CPVL,CREBL2,CROCC,CROCCP2,CRTAP,CSK,CSNK2A1,CST3,CSTB,CTBP2,CTDSP2,CTNNA1,CTNND1,CTSB,CTSC,CTSS,CUEDC2,CYB561A3,CYBB,CYC1,CYFIP1,CYP4V2,DAPK1,DCAF7,DCTD,DCTN2,DCTPP1,DDOST,DDX18,DDX60,DDX60L,DERA,DMAC1,DMXL1,DNASE2,DNLZ,DPAGT1,DPH3,DPP8,DPYD,DRG1,DTX3L,DYNC1I2,DYNLL1,EAF2,EBNA1BP2,ECHDC1,ECHS1,EFTUD2,EHBP1L1,EIF2AK1,EMILIN2,ENO1,ENY2,EPB41L3,ERCC1,ESRP2,ETFA,EXOC4,EXOSC1,EXOSC5,FAM110A,PCED1B,RTL8C,ANTKMT,PSME3IP1,GASK1B,COX20,PIEZO1,RMDN1,CIAO2A,FASTK,FBP1,FCER1G,FCGR1BP,FCN1,FGD2,FGD4,FGL2,FGR,FKBP15,FKBP5,FUCA1,GALNT2,GAS7,GATAD1,GCNT2,GDI2,GEMIN7,GIT2,SLX1B,GLRX,GLYR1,GNS,GOLIM4,GPAA1,GPBAR1,GRN,GRSF1,GSTO1,GSTP1,GTF2H2,GTF2H2C,GTF2H2C_2,GTF3C2,HAUS7,HCG18,HCK,PUDP,HEBP1,HFE,HHEX,HIPK2,HK1,HK3,HLA-DMB,HLA-DRB1,HM13,HMGN4,HNRNPA0,HOXA7,HPSE,HTATIP2,HVCN1,ICE2,IDH2,IDH3A,IDH3G,IFI16,IFI30,IFI35,IFT80,IGHG1,IGHM,IKZF1,IKZF3,IL10RB,IL17RA,ILK,INTS7,IRF5,IRF7,ITPR2,ITPRIPL2,JAK2,KCNE3,KCTD12,KIAA0513,KLHL36,KLHL6,KRTAP2-4,KYNU,LAIR1,LARP1,LARP4B,LARS1,LBHD1,LDAH,LEPROT,LILRA1,LILRB1,LIMS1,LMO2,LSM10,LSM6,LTA4H,LY6H,MANF,MAP2K1,MAP4,MAPK1,MARCHF1,MARCO,MAT2A,MAT2B,MED16,MEF2C,MEGF9,MESD,METTL7A,METTL8,MFSD1,MFSD14B,MGST3,MKKS,MLKL,MLX,MPEG1,MRM2,MRPL16,MRPL20,MRPL24,MRPL51,MRPS11,MRPS16,MRPS18C,MS4A4A,MS4A6A,MX1,MX2,MYCBP,MYD88,MYOF,N4BP2L1,NAAA,NADK,NAGA,NAGK,NAIP,NCOA2,NDUFAF3,NDUFB10,NDUFB3,NDUFB5,NDUFS2,NDUFS7,NECAP2,NIF3L1,NIPAL3,NOLC1,NOTCH2,NSL1,NUB1,NUDT22,NUDT5,NUP214,OAS1,OAS2,OAS3,OCIAD1,OGFOD1,ORAI3,ORMDL2,OSCAR,OCA2,PAICS,PANK2,PARP1,PARP12,PARP14,PCK2,PCMT1,PCMTD1,PDCD6,PDHB,PDIA6,PDLIM5,PDXK,PEA15,PECAM1,PGD,PGLS,PGM2,PHPT1,PIGP,PIK3AP1,PIK3C3,PLAC8,PLBD1,PLOD3,PLSCR1,PLXNB2,PMVK,POLK,PPA2,PPHLN1,PPID,PPP1R11,PPP1R7,PPT1,PRAM1,PRDX4,PRELID1,PREPL,PLPBP,PRPF19,PRPF6,PRR5L,PSMB10,PSMB2,PSMB9,PTBP1,PTGER2,PUSL1,PYCARD,QKI,RAB10,RAB27A,RAB3GAP1,RAB40C,RAB4B,RAB8A,RAP1GDS1,RASSF4,RB1,RBBP4,RBM8A,RDH11,REEP4,REEP5,RGS19,RHBDD1,RNF135,RNF20,RNF5,RNFT1,RNH1,RPRD2,RPUSD3,RRP12,RRP7A,RSL1D1,RTN1,RUBCN,RUFY3,RXRA,S100Z,SAMD9L,SAMHD1,SART3,SAT2,SBNO1,SCAMP2,SCARB2,SCPEP1,SDHC,SDR39U1,SEC22B,SEC23IP,SELENOH,SERBP1,SERF2,SERPINB1,SH2D3C,SHMT2,SHTN1,SIDT2,SLC12A7,SLC22A18,SLC24A1,SLC24A4,SLC25A24,SLC27A3,SLC2A6,SLC31A1,SLC7A7,SLX1A,SMARCA4,SMURF2,SNTB2,SNX1,SNX17,SNX2,SNX27,SNX6,SP110,SPTLC1,SPTLC2,SQOR,SRD5A3,SRGAP2C,SSB,SSR1,STAT1,STAT2,STX4,STX7,SUCLG1,SULT1A1,SUMF1,SUSD1,SYK,SYNCRIP,SYNE3,SYTL3,TAF4,TANGO2,TBC1D8,TBXAS1,TCF3,TCF4,TCF7L2,TICAM2,TIMM8B,TINF2,TKT,TLR7,TLR8,TM9SF1,TM9SF4,TMBIM4,TMED7-TICAM2,TMED9,TMEM126B,TMEM19,TMEM205,TMEM209,TMEM63A,TMEM80,TMPO,TMX1,TNFSF10,TNFSF12-TNFSF13,TNFSF13,TNFSF13B,TNRC6B,TNS3,TOR1A,TOR1B,TPI1,TPST2,TRAPPC3,TREX1,TRIM14,TRIM22,TRIM34,TRIM5,TRIM6-TRIM34,TRIM69,TRIO,TRIP11,TRMT112,TSPAN31,TSPAN4,UBE2I,UBE2L3,UCP2,UEVLD,UNC50,UNC93B1,USP19,USP34,VAV1,VPS41,VRK2,WSB1,XAF1,XIAP,XRCC5,YWHAB,YWHAE,YY1AP1,ZC3H4,ZFAND5,ZNF106,ZNF143,ZNHIT1 FOUNDER_NAMES