STANDARD_NAME RHODES_CANCER_META_SIGNATURE SYSTEMATIC_NAME M1345 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/RHODES_CANCER_META_SIGNATURE NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes commonly up-regulated in cancer relative to normal tissue, according to the meta-analysis of the OncoMine gene expression database. DESCRIPTION_FULL Many studies have used DNA microarrays to identify the gene expression signatures of human cancer, yet the critical features of these often unmanageably large signatures remain elusive. To address this, we developed a statistical method, comparative metaprofiling, which identifies and assesses the intersection of multiple gene expression signatures from a diverse collection of microarray data sets. We collected and analyzed 40 published cancer microarray data sets, comprising 38 million gene expression measurements from >3,700 cancer samples. From this, we characterized a common transcriptional profile that is universally activated in most cancer types relative to the normal tissues from which they arose, likely reflecting essential transcriptional features of neoplastic transformation. In addition, we characterized a transcriptional profile that is commonly activated in various types of undifferentiated cancer, suggesting common molecular mechanisms by which cancer cells progress and avoid differentiation. Finally, we validated these transcriptional profiles on independent data sets. PMID 15184677 GEOID AUTHORS Rhodes DR,Yu J,Shanker K,Deshpande N,Varambally R,Ghosh D,Barrette T,Pandey A,Chinnaiyan AM CONTRIBUTOR John Newman CONTRIBUTOR_ORG University of Washington EXACT_SOURCE Fig. 2A FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ACLY,AHCY,ARMET,C20orf1,C7orf14,CANX,CBX3,CCT4,CCT5,CDC2,CDKN3,CKS2,COL1A2,COPB2,CRIP2,DVL3,E2-EPF,E2F5,FAP,G3BP,HDAC1,HNRPA2B1,HSPD1,HSPE1,IARS,IFNGR2,ILF2,KDELR2,KIAA0101,KIAA0111,KPNA2,LDHA,MCM3,MMP9,MRPL3,MRPS12,MTHFD2,NCBP2,NME1,NONO,OGT,P100,PAFAH1B3,PAICS,PLK,PPP2R5C,PRDX4,PSMA1b,PSMC4,PSME2,PTMA,RBM4,RFC4,SDHC,SMARCA4,SNRPE,SNRPF,SOX4,SSBP1,SSR1,TARS,TGIF,TOP2A,TRA1,TRAF4,TSTA3,TUBB GENE_SYMBOLS ACLY,AHCY,MANF,TPX2,NUP205,CANX,CBX3,CCT4,CCT5,CDK1,CDKN3,CKS2,COL1A2,COPB2,CRIP2,DVL3,UBE2S,E2F5,FAP,G3BP1,HDAC1,HNRNPA2B1,HSPD1,HSPE1,IARS1,IFNGR2,ILF2,KDELR2,PCLAF,EIF4A3,KPNA2,LDHA,MCM3,MMP9,MRPL3,MRPS12,MTHFD2,NCBP2,NME1,NONO,OGT,,PAFAH1B3,PAICS,PLK1,PPP2R5C,PRDX4,,PSMC4,PSME2,PTMA,RBM4,RFC4,SDHC,SMARCA4,SNRPE,SNRPF,SOX4,SSBP1,SSR1,TARS1,TGIF1,TOP2A,HSP90B1,TRAF4,GFUS,TUBB FOUNDER_NAMES