STANDARD_NAME WALLACE_PROSTATE_CANCER_RACE_DN SYSTEMATIC_NAME M15671 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/WALLACE_PROSTATE_CANCER_RACE_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes down-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. DESCRIPTION_FULL The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared with European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical variables. We also evaluated 18 nontumor prostate tissues from seven African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a false-discovery rate of