STANDARD_NAME YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5 SYSTEMATIC_NAME M16708 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_5 NAMESPACE AFFY_MG_U74 DESCRIPTION_BRIEF Genes co-regulated in uterus during a time course response to progesterone [PubChem=5994]: SOM cluster 5. DESCRIPTION_FULL Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterine stromal cells. Hoxa-10 mutants express a stromal cell proliferation defect that is accompanied by quantitative or spatial alterations in the expression of two cyclin-dependent kinase inhibitor genes, p57 and p15. Hoxa-10 deficiency also leads to a severe local immunological disturbance, characterized by a polyclonal proliferation of T cells, that occurs in place of the normal progesterone-mediated immunosuppression in the periimplantation uterus. PMID 12554760 GEOID GSE106,GSE107 AUTHORS Yao MW,Lim H,Schust DJ,Choe SE,Farago A,Ding Y,Michaud S,Church GM,Maas RL CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Supp. data: out_b_data Web S6: Cluster No.=5 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 100080_at,100681_f_at,101144_at,102389_s_at,102798_at,103432_at,103520_at,104155_f_at,104643_at,160275_at,160349_at,160481_at,160564_at,160918_at,161835_at,92567_at,92820_at,93020_at,93619_at,93873_s_at,93875_at,93996_at,94384_at,95131_f_at,95673_s_at,96518_at,96591_at,97374_at,97950_at,98008_at,99322_at,99503_at,99602_at,99603_g_at,99622_at,99637_at GENE_SYMBOLS BPIFA2,,IL18R1,GAP43,ADM,ISG20,VEGFA,ATF3,WWC1,MSRB1,CNDP2,PCK1,LCN2,S100G,,COL5A2,USP2,BEX2,PER1,HOXA11-AS,HSPA1A,CYP2E1,IER3,NDUFB2,BASP1,WWC1,RELN,,XDH,CX3CL1,KCNQ1,PPTC7,KLF10,KLF10,KLF4,COL15A1 FOUNDER_NAMES