STANDARD_NAME YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN SYSTEMATIC_NAME M1208 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_DN NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Genes down-regulated in HUVEC cells (endothelium) by ETS1 [GeneID=2113] which were up-regulated by SP100 [GeneID=6672]. DESCRIPTION_FULL SP100 was first identified as a nuclear autoimmune antigen and is a constituent of the nuclear body. SP100 interacts with the ETS1 transcription factor, and we have previously shown that SP100 reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and uPA promoters. We now demonstrate that SP100 expression is upregulated by interferons, which have been shown to be antiangiogenic, in primary endothelial cells. As ETS1 is functionally important in promoting angiogenesis, we tested the hypothesis that ETS1 activity is negatively modulated by SP100 in endothelial cells. SP100 directly antagonizes ETS1-mediated morphological changes in human umbilical vein endothelial cell (HUVEC) network formation and reduces HUVEC migration and invasion. To further understand the functional relationship between ETS1 and SP100, cDNA microarray analysis was utilized to assess reprogramming of gene expression by ETS1 and SP100. A subset of the differentially regulated genes, including heat-shock proteins (HSPs) H11, HSPA1L, HSPA6, HSPA8, HSPE1 and AXIN1, BRCA1, CD14, CTGF (connective tissue growth factor), GABRE (gamma-aminobutyric acid A receptor epsilon), ICAM1, SNAI1, SRD5A1 (steroid-5-alpha-reductase 1) and THY1, were validated by real-time PCR and a majority showed reciprocal expression in response to ETS1 and SP100. Interestingly, genes that are negatively regulated by ETS1 and upregulated by SP100 have antimigratory or antiangiogenic properties. Collectively, these data indicate that SP100 negatively modulates ETS1-dependent downstream biological processes. PMID 15592518 GEOID AUTHORS Yordy JS,Moussa O,Pei H,Chaussabel D,Li R,Watson DK CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: [GFP+VEGF vs. SP100/GFP+VEGF] > 0 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AA001218,AA005111,AA010110,AA029890,AA056118,AA188710,AA233549,AA291389,AA425316,AA431203,AA432030,AA435948,AA447978,AA448395,AA464983,AA481022,AA485036,AA487465,AA504153,AA576333,AA576342,AA581078,AA581102,AA581123,AA581248,AA581429,AA581483,AA581501,AA598656,AA610064,AA620511,AA629849,AA634469,AA644586,AA701913,AA779293,AA847472,AA877935,AA910443,AA912458,AA916157,AA916192,AA916875,AA932521,AA971833,AA988857,AA991624,AI042114,AI263575,AI269774,AI269958,AI333932,AI371684,AI474686,AI492725,AI540460,AI582999,AI634715,AI677766,AI680547,AI691089,AI698340,AI816969,AI819473,AI826042,AI830281,AI832007,AI884498,AI885451,AI886795,AI920877,AI924973,AI926519,AI933043,AI952285,AI969665,AI983454,AW004895,AW005713,AW057705,AW075585,AW084638,H16833,H17513,H18646,H22825,H26086,H45668,H64096,H71225,H80748,H99426,N52496,N52837,N59295,R11775,R26732,R27431,R37817,R49718,R71124,T52201,T53705 GENE_SYMBOLS SOCS3,LMO7,HSPB8,PRKCA,TENT5C,,CFD,IRF9,CYB5R2,DNAJB6,,DNAJB1,ALDH1A2,TULP4,SNAI1,,HSPH1,,TYW3,,,PAX2,,,,,,,,TASOR,HSPA8,CACYBP,,PCDH9,,,APOA4,,CCN3,CHORDC1,,,,FKBP4,IRF4,SAMD9L,,ERCC6L2,AGO2,PHYH,,ZNF106,BAG3,SSUH2,CNR2,PTGES,CELA3B,HADH,BMX,BRCA1,MAGEA11,,ESPL1,,,MAGEA9B,TCL1B,MUC4,WNT7A,VAV1,ZNF91,KLRB1,AXIN1,AHSA1,COL4A3,CHL1,CELA3A,,SPINK1,FLT3,TNC,CA2,SRD5A1,HSPA1L,ZNF532,LMO7,PMP22,KLF4,,CPEB4,ZNF532,PTPRM,BTG3,ZMYND8,RASSF8,ZNF578,PMP22,TICAM2,LRIF1,,TENT5A,CLIC2,ANGPTL4 FOUNDER_NAMES