STANDARD_NAME ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN SYSTEMATIC_NAME M1751 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN NAMESPACE MOUSE_GENE_SYMBOL DESCRIPTION_BRIEF Genes with promoters bound by FOXP3 [GeneID=50943] and which are down-regulated only in mature (peripheral blood) regulatory CD4+ [GeneID=920] T lymphocytes. DESCRIPTION_FULL Transcription factor Foxp3 (forkhead box P3), restricted in its expression to a specialized regulatory CD4+ T-cell subset (T(R)) with a dedicated suppressor function, controls T(R) lineage development. In humans and mice, Foxp3 deficiency results in a paucity of T(R) cells and a fatal breach in immunological tolerance, causing highly aggressive multi-organ autoimmune pathology. Here, through genome-wide analysis combining chromatin immunoprecipitation with mouse genome tiling array profiling, we identify Foxp3 binding regions for approximately 700 genes and for an intergenically encoded microRNA. We find that a large number of Foxp3-bound genes are up- or downregulated in Foxp3+ T cells, suggesting that Foxp3 acts as both a transcriptional activator and repressor. Foxp3-mediated regulation unique to the thymus affects, among others, genes encoding nuclear factors that control gene expression and chromatin remodelling. In contrast, Foxp3 target genes shared by the thymic and peripheral T(R) cells encode primarily plasma membrane proteins, as well as cell signalling proteins. Together, our studies suggest that distinct transcriptional sub-programmes implemented by Foxp3 establish T(R) lineage during differentiation and its proliferative and functional competence in the periphery. PMID 17237761 GEOID AUTHORS Zheng Y,Josefowicz SZ,Kas A,Chu TT,Gavin MA,Rudensky AY CONTRIBUTOR Jessica Robertson CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S: periphery only FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 2900024C23Rik,5830405N20Rik,5830407E08Rik,6720418B01Rik,A230061C15Rik,A430107P09Rik,A630081D01Rik,Abtb2,Ankrd44,B930053N05Rik,Bach2,Bcl11b,Bcl2,C230085N15Rik,Clec2d,Cmah,Cpe,D13Ertd787e,D730035F11Rik,D8Ertd82e,Dph5,E430014B02Rik,EG628919,Foxp1,Gfi1,Jak1,Lef1,Lrch1,Ms4a4b,Ms4a6c,Nipbl,Nrip1,P2ry5,Pctk2,Peli1,Ptger3,Ptk2b,Ptprc,Rapgef6,Rcbtb2,Rod1,Satb1,Scml4,St8sia1,Stk10,Syne2,Tgfbr2,Trim34,Utrn,Waspip,Wnk1 GENE_SYMBOLS DIPK1A,TESPA1,,,,,,ABTB2,ANKRD44,,BACH2,BCL11B,BCL2,,CLEC2D,CMAHP,CPE,,,PRAG1,DPH5,,,FOXP1,GFI1,JAK1,LEF1,LRCH1,,,NIPBL,NRIP1,LPAR6,CDK17,PELI1,PTGER3,PTK2B,PTPRC,RAPGEF6,RCBTB2,PTBP3,SATB1,SCML4,ST8SIA1,STK10,SYNE2,TGFBR2,TRIM34,UTRN,WIPF1,WNK1 FOUNDER_NAMES