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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="ALONSO_METASTASIS_NEURAL_UP" SYSTEMATIC_NAME="M19437" HISTORICAL_NAMES="" PMID="17409456" AUTHORS="Alonso SR,Tracey L,Ortiz P,Pérez-Gómez B,Palacios J,Pollán M,Linares J,Serrano S,Sáez-Castillo AI,Sánchez L,Pajares R,Sánchez-Aguilera A,Artiga MJ,Piris MA,Rodríguez-Peralto JL" GEOID="" EXACT_SOURCE="Table 4" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jessica Robertson" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Neural-related genes up-regulated in melanoma tumors that developed metastases compared to primary melanoma that did not." DESCRIPTION_FULL="Metastatic disease is the primary cause of death in cutaneous malignant melanoma (CMM) patients. To understand the mechanisms of CMM metastasis and identify potential predictive markers, we analyzed gene-expression profiles of 34 vertical growth phase melanoma cases using cDNA microarrays. All patients had a minimum follow-up of 36 months. Twenty-one cases developed nodal metastatic disease and 13 did not. Comparison of gene expression profiling of metastatic and nonmetastatic melanoma cases identified 243 genes with a &gt;2-fold differential expression ratio and a false discovery rate of &lt;0.2 (206 up-regulated and 37 down-regulated). This set of genes included molecules involved in cell cycle and apoptosis regulation, epithelial-mesenchymal transition (EMT), signal transduction, nucleic acid binding and transcription, protein synthesis and degradation, metabolism, and a specific group of melanoma- and neural-related proteins. Validation of these expression data in an independent series of melanomas using tissue microarrays confirmed that the expression of a set of proteins included in the EMT group (N-cadherin, osteopontin, and SPARC/osteonectin) were significantly associated with metastasis development. Our results suggest that EMT-related genes contribute to the promotion of the metastatic phenotype in primary CMM by supporting specific adhesive, invasive, and migratory properties. These data give a better understanding of the biology of this aggressive tumor and may provide new prognostic and patient stratification markers in addition to potential therapeutic targets." TAGS="" MEMBERS="AKT1S1,ALS4,APLP2,CD63,CHN1,EMP1,ENC1,KIT,MAGEA6,MAL,MASA,MITF,PDGFRA,PMP22,PTPRZ1,S100A10,SDCBP,SEPP1" MEMBERS_SYMBOLIZED="AKT1S1,APLP2,CD63,CHN1,EMP1,ENC1,KIT,L1CAM,MAGEA6,MAL,MITF,PDGFRA,PMP22,PTPRZ1,S100A10,SDCBP,SELENOP,SETX" MEMBERS_EZID="1123,2012,23064,334,3815,3897,4105,4118,4286,5156,5376,5803,6281,6386,6414,84335,8507,967" MEMBERS_MAPPING="AKT1S1,AKT1S1,84335|ALS4,SETX,23064|APLP2,APLP2,334|CD63,CD63,967|CHN1,CHN1,1123|EMP1,EMP1,2012|ENC1,ENC1,8507|KIT,KIT,3815|MAGEA6,MAGEA6,4105|MAL,MAL,4118|MASA,L1CAM,3897|MITF,MITF,4286|PDGFRA,PDGFRA,5156|PMP22,PMP22,5376|PTPRZ1,PTPRZ1,5803|S100A10,S100A10,6281|SDCBP,SDCBP,6386|SEPP1,SELENOP,6414" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
